Adrenal gland & paraganglia
Other tumors
Adenomatoid tumor
Author: Lan L. Gellert, M.D., Ph.D.
Topic Completed: 1 August 2016
Minor changes: 4 February 2021
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: Adrenal adenomatoid tumor
Table of Contents
Definition / general | Essential features | Epidemiology | Etiology | Clinical features | Prognostic factors | Case reports | Treatment | Clinical images | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Differential diagnosisCite this page: Gellert LL. Adenomatoid tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/adrenaladenomatoid.html. Accessed May 15th, 2021.
Definition / general
- Benign neoplasm of mesothelial origin
Essential features
- Benign neoplasm of mesothelial origin
- Very rare, mostly incidental finding
- In the differential diagnosis of adrenal mass
- Immunostains help establish the diagnosis
Epidemiology
- Mean age 41 years, range 31-64 years
- 90% male
Etiology
- Mesothelial origin based on ultrastructural and immunohistochemical findings (Arch Pathol Lab Med 1990;114:722 )
Clinical features
- Mostly asymptomatic and discovered incidentally
Prognostic factors
- Metastasis or recurrences have not been reported
Case reports
- 22 year old man with HIV infection and hypermetabolic right adrenal mass (Rare Tumors 2011;3:e21)
- 24 year old man with germline SDHD mutation and adrenal adenomatoid tumor (Pathology 2011;43:495)
- 26 year old man with adrenal adenomatoid tumor mimicking echinococcus cyst of the liver (Int J Surg 2008;6:485)
- 32 year old man with a left adrenal gland mass (Indian J Pathol Microbiol 2013;56:319)
- 33 year old man with a 2 cm tumor (Arch Pathol Lab Med 2003;127:1633)
- 40 year old man with an incidental adrenal mass (BMJ Case Rep 2015 Aug 4;2015)
- 44 year old man with giant cystic mass in left adrenal gland (Chin Med J (Engl) 2010;123:372)
- 47 year old man with 7 cm composite adrenal cortical adenoma and adenomatoid tumor in right adrenal gland (Endocr Pathol 2015;26:370)
- 51 year old man with tumor and micronodular adrenal cortical hyperplasia (Hum Pathol 2003;34:818)
- 62 year old Chinese man with cystic lymphangioma-like adenomatoid tumor in right adrenal gland (Int J Clin Exp Pathol 2013;6:943)
- A hypertensive patient with adrenal mass and clinical impression of pheochromocytoma (Arch Pathol Lab Med 1990;114:725)
- Two cases of composite adenomatoid tumor and myelolipoma in adrenal gland (Arch Pathol Lab Med 2008;132:265)
Treatment
- Surgical excision
Clinical images
Images hosted on other servers:
Adenomatoid tumor in left adrenal gland
Well circumscribed,
expansile hypodense mass
in right adrenal gland
Gross description
- 1-4 cm, well circumscribed, white-tan-gray, and occasional cystic mass
Gross images
Images hosted on other servers:
Adenomatoid tumor in left adrenal gland
Cut surface of cystic lymphangioma-like
adrenal adenomatoid tumor
Microscopic (histologic) description
- Adenoid, angiomatoid, cystic and solid patterns of anastomosing glands and tubules of variable size
- Flat to low cuboidal neoplastic cells with occasional cytoplasmic vacuoles and signet ring cell like morphology
- Cells have low nuclear / cytoplasmic ratio
- No or rare mitotic activity
- Involves adrenal tissue and often extends into adjacent fat
Microscopic (histologic) images
Images hosted on other servers:
H&E and immunostains of adrenal adenomatoid tumor
Cystic lymphangioma-like adenomatoid tumor
Tumor admixed with
lymphoid follicular hyperplasia
Electron microscopy description
- Well formed desmosomes, extensively developed microvilli
Differential diagnosis
- Adrenal cyst
- Angiosarcoma
- Hemangioma
- Lymphangioma
- Malignant mesothelioma
- Metastatic adenocarcinoma - including signet-ring cell
- Yolk sac tumor
