Adrenal gland & paraganglia

Adrenal hyperfunction / hyperplasia

Adrenal cytomegaly

Topic Completed: 1 February 2005

Minor changes: 3 May 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Adrenal cytomegaly

Nat Pernick, M.D.
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Cite this page: Pernick N. Adrenal cytomegaly. website. Accessed December 3rd, 2021.
Definition / general
  • Relatively common finding within fetal cortex in newborns, particularly premature infants (3-7%) or infants with Rh incompatibility
  • May be associated with Beckwith-Wiedemann syndrome
  • Cells do NOT represent carcinoma in situ
  • Pseudoinclusions (Arch Pathol Lab Med 1981;105:358)
Case reports
Gross description
  • Hyperplastic adrenal glands
Microscopic (histologic) description
  • Numerous, markedly enlarged (up to 150 microns) and bizarre polyhedral cells with eosinophilic, granular cytoplasm and large, hyperchromatic nuclei with pseudoinclusions in adrenal cortex
  • No / rare mitotic figures
Differential diagnosis
  • CMV infection: usually infants, basophilic cytoplasm and large intranuclear inclusion surrounded by a clear halo
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