Adrenal gland & paraganglia

Other tumors


Last author update: 1 June 2016
Last staff update: 12 November 2020

Copyright: 2002-2022,, Inc.

PubMed Search: Lymphoma [title] adrenal

Lan L. Gellert, M.D., Ph.D.
Page views in 2021: 454
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Cite this page: Gellert LL. Lymphoma. website. Accessed August 11th, 2022.
Definition / general
    Primary adrenal lymphoma:
    • Rare, < 200 cases reported
    • Usually presents with bilateral adrenal masses, often with adrenal hypofunction
    • Subtype usually diffuse large B cell lymphoma
    Secondary adrenal involvement is common
    • Adrenal involvement in up to 25% with disseminated lymphoma at autopsy
    • Usually no associated adrenal insufficiency
Essential features
  • Primary adrenal lymphoma is rare
    • Most cases have bilateral adrenal involvement and adrenal insufficiency
    • Diffuse large B cell lymphoma most common
Clinical features
Radiology images

Images hosted on other servers:

Bilateral, homogenous adrenal gland enlargement

Fluorodeoxyglucose PET

Prognostic factors
  • Poor prognosis; most die within one year
  • Adrenal insufficiency and administration of chemotherapy are significant prognostic factors (Ann Hematol 2013;92:1583)
  • CNS involvement adversely affects long term prognosis (Ann Hematol 2013;92:1583)
Case reports
  • Surgery and chemotherapy
  • CHOP / CHOP-like chemotherapy regimen plus rituximab
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:

Primary adrenal gland diffuse large B cell lymphoma is CD45+, CD20+

Primary adrenal gland Hodgkin lymphoma

Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis
  • Metastatic carcinoma: Cytokeratin+, negative for lymphoid markers
  • Metastatic melanoma: S100+, MelanA+, HMB45+
  • Primary adrenal tumor: negative for lymphoid markers
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