Adrenal gland & paraganglia
Adrenal hyperfunction / hyperplasia
Massive macronodular adrenocortical disease

Topic Completed: 1 January 2017

Minor changes: 15 January 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Massive macronodular adrenocortical disease

Lan L. Gellert, M.D., Ph.D.
Page views in 2019: 204
Page views in 2020 to date: 153
Cite this page: Gellert LL. Massive macronodular adrenocortical disease. website. Accessed August 7th, 2020.
Definition / general
Essential features
  • ACTH independent multinodular adrenocortical proliferation
  • Usually bilateral
  • Occasionally associated with hereditary leiomyomatosis and renal cell cancer (HLRCC) or McCune-Albright syndrome
Clinical features
  • Usually present with either typical or atypical Cushing syndrome
Case reports
  • Adrenalectomy
Clinical images

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Macronodular adrenocortical
hyperplasia of the zona reticularis

Gross description
  • Glands up to 180 g, nodules up to 4 cm and nonnodular cortex may be atrophic
Gross images

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AIMAH patient 1

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AIMAH patient 2

Microscopic (histologic) description
  • Predominantly diffuse and vaguely nodular proliferation of clear cortical cells
Microscopic (histologic) images

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A quantitative RT-PCR array

Positive stains
Differential diagnosis
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