Small intestine & ampulla
Ampulla
Adenomyoma
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 December 2012
Last staff update: 1 September 2020
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Adenomyoma
Table of Contents
Definition / general | Case reports | Treatment | Gross description | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosisCite this page: Gulwani H. Adenomyoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ampullaadenomyoma.html. Accessed April 18th, 2024.
Definition / general
- Also called adenomyomatous hyperplasia
- Rare, benign
- Usually stomach, duodenum, jejunum
- Often causes pain in right upper quadrant, radiating to back
- May cause biliary obstruction and common bile duct dilation (Arch Pathol Lab Med 1987;111:388)
Case reports
- 55 year old woman with history of duodenal ulcers (Arch Pathol Lab Med 2001;125:701)
- 74 year old woman presenting as acute recurrent pancreatitis (World J Gastroenterol 2007;13:2892)
Treatment
- Excision
Gross description
- Mass at head of pancreas, usually 0.5 cm or more
Microscopic (histologic) description
- Well circumscribed, nodular proliferation of smooth muscle cells, ducts and glands, clearly disorganized compared to normal
- Ducts and glands are lined by columnar/cuboidal cells
- No atypia, no mitoses, usually no pancreatic tissue
Positive stains
- MUC6, focal surface positivity for MUC5AC (J Hepatobiliary Pancreat Sci 2010;17:275)
Negative stains
- MUC1, MUC4
Differential diagnosis
- Normal intraampullary common bile duct (normally has dense muscular layer)
- Ectopic pancreatic tissue
- Fibroadenoma
- Brunner gland hyperplasia
