Anus & perianal area
Paget disease

Topic Completed: 1 November 2014

Minor changes: 19 August 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Paget disease anus "loattrfree full text"[sb]

Raul S. Gonzalez, M.D.
Page views in 2019: 1,207
Page views in 2020 to date: 764
Cite this page: Gonzalez RS. Paget disease. website. Accessed August 8th, 2020.
Definition / general
  • Intraepithelial tumor of apocrine or possibly eccrine gland origin
  • Primary extramammary anal Paget disease is rare
  • Men and women are equally affected
  • Most often occurs in the fifth to seventh decade
  • Typically indolent but often recurs
  • About 15% of patients with anal Paget have secondary disease (associated with an underlying malignancy)
  • Arises anywhere between the dentate line and the perianal skin
Clinical images

Images hosted on other servers:

Extensive perianal Paget disease, perineum

Early response

Notable telangiectasia and fibrosis

Gross description
  • Erythematous, ulcerated or eczematous plaques or patches
Microscopic (histologic) description
  • Large, pale staining to clear intraepidermal neoplastic cells containing abundant mucin, arranged singly or occasionally in nests or gland-like formations
  • Cells are more numerous basally
  • Microscopic disease may extend beyond grossly visible changes
  • Associated changes include squamous hyperplasia, fibroepithelioma-like hyperplasia and papillomatous hyperplasia (Am J Surg Pathol 2000;24:543)
Microscopic (histologic) images

Images hosted on other servers:

Anal Paget disease (lower image)


Secondary anal Paget disease
(first image) with associated

Positive stains
Negative stains
Differential diagnosis
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