Granulomatous appendicitis

Topic Completed: 1 August 2012

Minor changes: 20 August 2019

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PubMed Search: Granulomatous appendicitis

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Cite this page: Mansouri J. Granulomatous appendicitis. website. Accessed October 18th, 2021.
Definition / general
  • Identified in 0.1% to 2.0% of appendectomies
  • Clinically resembles acute appendicitis
  • Does not recur after appendectomy; only 5-10% develop Crohn’s disease in GI tract (Hum Pathol 1986;17:1116)
  • Causes: usually idiopathic; also Yersinia, foreign body reactions, interval appendicitis, Mycobacterium tuberculosis, pinworm (Enterobius vermicularis), sarcoidosis
Case reports
Microscopic (histologic) description
  • Resembles Crohn’s disease with focal cryptitis, crypt abscesses, mucosal erosion and ulceration, fissures, transmural lymphoid aggregates, mural fibrosis
  • More granulomas than Crohn’s (20 vs. 0.3 per tissue section, Hum Pathol 1993;24:595)
  • Usually no fistulas
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