Cite this page: Mansouri J. Adenovirus & measles. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/appendixmeasles.html. Accessed July 24th, 2021.
Adenovirus
- Associated with marked lymphoid hyperplasia leading to intussusception, usually in children
- Viral nuclear inclusions: basophilic nuclei with indistinct nuclear membranes (Cowdry type B, smudge cells) and, less commonly, eosinophilic inclusions surrounded by halos and distinct nuclear membranes (Cowdry type-A)
- Immunohistochemistry, PCR, and in situ hybridization helpful in diagnosis (Infect Dis Clin North Am 2010;24:995)
Measles
- Associated with appendicitis in prodromal measles stage; rash may not appear until after appendix is removed (Scand J Infect Dis 2001;33:632)
- Microscopic description: marked lymphoid hyperplasia, multinucleated giant cells (Warthin-Finkeldey type) in germinal centers (Infect Dis Clin North Am 2010;24:995)
Microscopic (histologic) images
Contributed by Dr. Oleksandr Grygoruk, Boris Hospital and Medical Center, Kiev (Ukraine)
40 year old woman with prodromal measles confirmed by serology
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Warthin-Finkeldey cells (lymph node)
