Signet ring cell adenocarcinoma

Topic Completed: 1 August 2012

Minor changes: 19 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Signet ring cell adenocarcinoma

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Cite this page: Mansouri J. Signet ring cell adenocarcinoma. website. Accessed October 18th, 2021.
Definition / general
  • Rare tumor in appendix with poor prognosis
  • May occur with goblet cell carcinoid
  • Stage using TNM, based on depth of malignant epithelioid cells, not depth of dissecting mucus
Case reports
  • Right hemicolectomy, remove mucus and peritoneal implants carefully
  • Debulk if recurrent disease
Microscopic (histologic) description
  • Resembles similar tumor elsewhere in GI tract
Microscopic (histologic) images

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Various images

Differential diagnosis
  • Goblet cell carcinoid: arises from glandular mucosa, spares luminal mucosa, insular pattern, no desmoplasia, better prognosis
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