Bladder, ureter & renal pelvis
Other tumors

Topic Completed: 1 December 2014

Minor changes: 11 February 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Bladder angiosarcoma

Turki Al-Hussain, M.D.
Page views in 2020: 355
Page views in 2021 to date: 318
Cite this page: Al-Hussain T. Angiosarcoma. website. Accessed August 4th, 2021.
Definition / general
  • Rare vascular tumor with anastomosing vascular channels
  • Endothelial cells usually exhibit marked cytologic atypia
  • Mean age 64 years, 89% occur in males
  • Due to radiation therapy for pelvic malignancy in 1/3; also exposure to arsenic, thorium dioxide, polyvinyl chloride or chemotherapeutic agents
  • It has been reported to arise in bladder with preexisting hemangioma
Clinical features
Case reports
  • Wide radical resection, possibly radiotherapy/chemotherapy
Gross description
  • Hemorrhagic, raised mass (mean 7 cm) of trigone or dome
Microscopic (histologic) description
  • Anastomosing vascular channels lined by plump hyperchromatic cells
  • Also solid growth and epithelioid cytology
  • Typically invades the muscularis propria (Am J Surg Pathol 2008;32:1213)
Positive stains
Differential diagnosis
  • Hemangioma: typically 1 cm or less, 80% are cavernous, no atypia, no anastomosing or solid areas
  • Kaposi’s sarcoma: associated with HIV and HHV8; extravasated red blood cells present; usually less atypia than angiosarcoma
  • Sarcomatoid urothelial carcinoma: undifferentiated spindle cells; associated urothelial carcinoma; vascular markers are negative
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