Bladder, ureter & renal pelvis

Other nonneoplastic


Topic Completed: 1 July 2011

Minor changes: 23 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Bladder endocervicosis

Alcides Chaux, M.D.
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Cite this page: Chaux A. Endocervicosis. website. Accessed October 17th, 2021.
Definition / general
  • Rare benign tumor-like lesions characterized by prominent endocervical-type glands in muscularis propria
  • Women in reproductive years (mean age 39 years, range 34-65 years)
  • Also men receiving estrogen for prostate cancer
  • Posterior wall or posterior dome preferentially affected
Clinical features
Case reports
  • Excision
Gross description
  • Mass between bladder and uterus in posterior bladder wall, dome or trigone
  • Up to 2.5 to 3.0 cm in size
  • Spongy cut surface with mucinous / milky fluid
Microscopic (histologic) description
  • Irregular proliferation of prominent endocervical-type glands in muscularis propria, less frequently in lamina propria or subserosal connective tissue
  • Glands are irregular in size and shape and may be cystically dilated, containing mucinous secretions with neutrophils
  • Glands are lined by a single layer of tall mucinous columnar cells, less commonly flat or cuboidal cells, rarely ciliated or goblet-like cells
  • Focal glandular rupture leads to mucin accumulation within the stroma with a fibroblastic-histiocytic response
  • Absent or mild nuclear atypia, no mitotic figures
  • No desmoplasia, no glandular crowding or back-to-back architecture
Microscopic (histologic) images

Images hosted on other servers:

glands in
muscularis propria

Complex cystic lesion
is embedded in
dense stroma and
smooth muscle

Lining epithelium has single layer of columnar cells with granular mucinous apical cytoplasm identical to endocervix

Positive stains
Differential diagnosis
  • Adenocarcinoma: marked atypia, mitotic figures
  • Adenoma malignum from uterine cervix: infiltration of bladder serosa, deep cervical involvement, glands are variable in shape or size with irregular or claw-shaped outlines
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