Bladder & ureters
Other tumors

Topic Completed: 1 December 2014

Minor changes: 27 June 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Bladder osteosarcoma

Page views in 2019: 173
Page views in 2020 to date: 88
Cite this page: Levy G. Osteosarcoma. website. Accessed May 29th, 2020.
Definition / general
  • Malignant mesenchymal tumor with osteoid formation
  • Sarcomas comprise < 1% of malignant bladder tumors
  • Rare; < 50 cases reported
  • 80% male
  • Mean age 64 years, range 41 to 86 years
  • Usually trigone
  • Patients may have prior or simulataneous urothelial carcinoma
Clinical features
  • Associated with urinary tract schistosomiasis
  • Patients present with hematuria, urgency and dysuria
Prognostic factors
  • Poor prognosis
  • Most patients die within 6 months due to local spread with urinary tract obstruction and secondary infection
Case reports
  • Radical cystectomy, radiation and chemotherapy
  • Occasionally responsive to radiotherapy and chemotherapy
Gross description
  • Large, polypoid, infiltrative, often gritty tumor
Microscopic (histologic) description
  • High grade sarcoma with spindle cells showing marked pleomorphism; no definite carcinomatous component
  • Abundant lace-like osteoid
  • May have chondroid matrix in background
Microscopic (histologic) images

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Hypercellular tumor

Cytology description
  • Spindle cell lesion with marked nuclear pleomorphism
Positive stains
Differential diagnosis
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