Bladder, ureter & renal pelvis

Other tumors


Topic Completed: 1 December 2014

Minor changes: 20 October 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Bladder plasmacytoma

Gillian Levy, M.D.
Page views in 2020: 1,013
Page views in 2021 to date: 832
Cite this page: Levy G. Plasmacytoma. website. Accessed December 8th, 2021.
Definition / general
  • Neoplastic proliferation of plasma cells; may be associated with multiple myeloma
  • Plasma cell neoplasm composed of plasma cells in any stage of differentiation
  • Rare in bladder
  • Most patients have known multiple myeloma or develop multiple myeloma
Clinical features
  • Tumors look and act like solid tumors
  • May be associated with serum and urine monoclonal immunoglobulins
  • May recur, usually don’t cause death
Case reports
Gross description
  • Single or nodular mass of bladder wall
Microscopic (histologic) description
  • Mature and immature plasmacytoid forms, including giant cells
  • Tumor cells have typical plasma cell morphology with eccentric nuclei and perinuclear hoffs or can be atypical with giant cells
Cytology description
Positive stains
  • CD138+, weakly positive for CD20 and CD45RB, variably positive for EMA; may express IgA or IgM
  • Restricted light chain expression (kappa or lambda but not both)
Negative stains
  • Keratin
Differential diagnosis
Additional references
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