Bladder, ureter & renal pelvis
Other nonneoplastic
Pseudocarcinomatous epithelial hyperplasia
Author: Nat Pernick, M.D.
Last author update: 1 June 2011
Last staff update: 12 November 2021
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Pseudocarcinomatous epithelial hyperplasia
Table of Contents
Definition / general | Clinical features | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Additional referencesCite this page: Pernick N. Pseudocarcinomatous epithelial hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bladderpseudocarcinoma.html. Accessed September 25th, 2023.
Definition / general
- Rare reactive condition that resembles carcinoma, initially described postradiation (Hum Pathol 2000;31:678, Am J Surg Pathol 2004;28:909)
- Also associated with ischemia and chronic radiation (Am J Surg Pathol 2008;32:92)
Clinical features
- Associated with radiation therapy; also ischemia and chronic irritation
- No treatment is required for this reactive condition
Case reports
- 55 year old woman with hematuria (Case of the Week #198)
Microscopic (histologic) description
- Downward proliferation of urothelial pseudoinvasive nests with focal squamous metaplasia but without atypia
- Nests wrap around vessels with fibrin deposition and congestion
- May have retraction artifact
- These nests, especially because of their irregular shape, can resemble invasive carcinoma; however, morphology is not typical of early invasive urothelial carcinoma
- Frequently hemorrhage, thickened vessels and other radiation associated vascular changes are present
- Fibrin deposition, fibrin thrombi, fibrosis, inflammation, hemosiderin, ulceration, edema and vascular congestion
- No mitotic figures
Microscopic (histologic) images
Case of the Month #198
Various images
Additional references
