Bladder, ureter & renal pelvis
Squamous cell neoplasms
Verrucous carcinoma

Topic Completed: 1 August 2019

Minor changes: 1 August 2020

Copyright: (c) 2003-2019,, Inc.

PubMed Search: Verrucous squamous cell carcinoma[title]

Related topics: Squamous cell carcinoma, Basaloid

Monika Roychowdhury, M.D.
Page views in 2019: 125
Page views in 2020 to date: 184
Cite this page: Roychowdhury, M. Verrucous carcinoma. website. Accessed August 7th, 2020.
Definition / general
  • Almost all cases are associated with Schistosoma hematobium infection
  • Indolent growth, spreads by direct extension
  • Does not metastasize, although may develop foci of invasive squamous cell carcinoma
Gross description
  • Exophytic, papillary tumor which projects into bladder lumen
Microscopic (histologic) description
  • Bulbous fronds of well differentiated, acanthotic epithelium with pushing margin, minimal atypia
  • No/rare mitotic figures
  • May resemble condyloma focally
Microscopic (histologic) images
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Polypoid areas

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Well-differentiated squamous epithelium

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Minimal cytologic and architectural atypia

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Condylomatous features

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