Bladder, ureter & renal pelvis
Cystitis
Xanthogranulomatous cystitis
Author: Turki Al-Hussain, M.D.
Last author update: 1 June 2016
Last staff update: 23 November 2020
Copyright: 2003-2022, PathologyOutlines.com, Inc.
PubMed Search: Xanthogranulomatous [title] cystitis
Table of Contents
Definition / general | Clinical features | Case reports | Treatment | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosisCite this page: Al-Hussain T. Xanthogranulomatous cystitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bladderxanthogranulomatous.html. Accessed December 1st, 2022.
Definition / general
- Rare (<50 cases reported in bladder) inflammatory disorder characterized by lipid-laden macrophages
Clinical features
- Benign, but associated with malignancy in some cases (Histopathology 1998;33:212)
- Associated with xanthogranulomatous pyelonephritis, urachal adenomas, inflammatory bowel disease
Case reports
- 50 year old man with multiple small polypoidal growths (Int Urol Nephrol 2007;39:477)
- 76 year old man with painless hematuria and bladder mass (Int Urogynecol J Pelvic Floor Dysfunct 2007;18:1233)
Treatment
- Broad spectrum antibiotics; possibly resection
Microscopic (histologic) description
- Lipid-laden macrophages, plasma cells and lymphocytes
- May have some Touton-type giant cells
- Similar to malakoplakia but without Michaelis-Gutmann bodies
Negative stains
Differential diagnosis
- Malakoplakia: has Michaelis-Gutmann bodies
- Urothelial carcinoma: cytokeratin positive
