Bone & joints

Other chondrogenic tumors

Periosteal chondroma



Topic Completed: 1 August 2013

Minor changes: 19 October 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Chondroma[title]

Nat Pernick, M.D.
Page views in 2020: 6,443
Page views in 2021 to date: 2,813
Cite this page: Pernick N Periosteal chondroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonechondroma.html. Accessed October 25th, 2021.
Definition / general
  • Benign cartilaginous tumor
  • Either enchondroma (arise from diaphyseal medullary cavity), subperiosteal/juxtacortical chondroma or soft tissue chondroma
  • Cytofluorometric DNA ploidy analysis may be useful in distinguishing these tumors from chondrosarcomas (Mod Pathol 1999;12:863)
Clinical features
  • Juxtacortical (periosteal) chondroma
    • Rare
    • Usually 3 cm or less
    • Surface of long bone or small bones of hand / feet
    • Usually teens to twenties, more common in males
    • Sites: metaphysis or shaft of tubular bones; may arise in zones lacking periosteum such as the femoral neck
    • Am J Surg Pathol 1985;9:666
Radiology description
  • Periosteal: well defined, 2 - 4 cm, sharply scallops outer cortex of underlying bone
Radiology images

AFIP images

Periosteal chondroma

Treatment
  • Excision
  • May recur if incompletely excised
Case reports
Gross description
  • Periosteal: single periosteal mass, often with internal calcifications
Gross images
AFIP images

Periosteal chondroma



 Contributed by Dr. Mark R. Wick

Periosteal

Microscopic (histologic) description
  • Juxtacortical (periosteal) chondroma
    • Benign hyaline cartilage tumor covered by periosteum or reactive bone
    • Hypercellular with variable myxoid features and binucleation
    • Does not invade surrounding tissue, no mitotic figures
Microscopic (histologic) images

AFIP images

Periosteal chondroma

Molecular / cytogenetics description
  • 12q13-15 (HMGA2 / HMGI-C) is involved in structural rearrangements (also in other benign mesenchymal tumors, Mod Pathol 2003;16:1132)
Back to top
Image 01 Image 02