Bone & joints
Fibrogenic / fibrohistiocytic tumors
Desmoplastic fibroma of bone
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 30 December 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed search: desmoplastic fibroma [title] bone
Table of Contents
Definition / general | Radiology description | Case reports | Treatment | Gross description | Microscopic (histologic) description | Molecular / cytogenetics description | Electron microscopy description | Differential diagnosis | Additional referencesCite this page: Pernick N. Desmoplastic fibroma of bone. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonedesmoplasticfibroma.html. Accessed June 4th, 2023.
Definition / general
- Rare, benign / borderline behavior; bony counterpart of soft tissue fibromatosis
- 75% younger than age 30 years, may be more common in males
- Sites: metaphysis of long bones (56%), mandible (26%), pelvis (14%)
Radiology description
- Lytic and honeycombed (“soap bubble” appearance) metaphyseal lesions, cortical thinning with soft tissue extension
Case reports
- 19 year old man with rib lesion (Arch Pathol Lab Med 2002;126:721)
Treatment
- Wide local excision to prevent otherwise frequent recurrences
- Causes local destruction, no metastases
Gross description
- White gray, fibrous rubbery mass with variable bony spicules and cysts
Microscopic (histologic) description
- Mature, bland fibroblasts separated by abundant collagen with thin walled, dilated vascular channels
- May infiltrate into soft tissue
- No necrosis, no pleomorphism or atypia, no mitotic activity
Molecular / cytogenetics description
- Trisomy 8, trisomy 20
Electron microscopy description
- Predominantly myofibroblasts, also fibroblasts and primitive mesenchymal cells
Differential diagnosis
Additional references
