Bone & joints

Other tumors

Giant cell granuloma

Topic Completed: 1 June 2005

Minor changes: 30 December 2020

Copyright: 2003-2021,, Inc.

PubMed search: giant cell granuloma [title] bone

Nat Pernick, M.D.
Page views in 2020: 6,362
Page views in 2021 to date: 6,136
Cite this page: Pernick N. Giant cell granuloma. website. Accessed October 25th, 2021.
Definition / general
  • Formerly called giant cell reparative granuloma
  • Giant cell lesion primarily of jaw, also other craniofacial bones and short tubular bones of hands and feet
  • May be response to injury but some cases behave aggressively
  • Giant cells have features of macrophages and osteoclasts; mononuclear cells appear to be proliferative, not giant cells
Radiology images

AFIP images


Contributed by Dr. Mark R. Wick


Foot Xray

Jaw Xray

Peripheral type, distal tibia

Case reports
Gross description
  • Unencapsulated, brittle, brown purple, granulation tissue mass
Microscopic (histologic) description
  • Fibrillar connective tissue stroma with small oval and spindly mononuclear cells mixed with uneven clusters of multinuclear (5 - 40) giant cells
  • Small capillaries, hemorrhage, hemosiderin, reactive bone with osteoblastic rimming
  • No pleomorphism, no / rare mitotic figures
Microscopic (histologic) images

AFIP images

Background is fibrous stroma

Giant cells present in granuloma-like aggregates

Contributed by Dr. Mark R. Wick


Positive stains
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