Table of Contents
Definition / general | Radiology images | Case reports | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Additional referencesCite this page: Pernick N. Giant cell granuloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonegiantcellreparative.html. Accessed March 4th, 2021.
Definition / general
- Formerly called giant cell reparative granuloma
- Giant cell lesion primarily of jaw, also other craniofacial bones and short tubular bones of hands and feet
- May be response to injury but some cases behave aggressively
- Giant cells have features of macrophages and osteoclasts; mononuclear cells appear to be proliferative, not giant cells
Radiology images
Case reports
- 32 year old man with giant cell granuloma of the temporal bone (Arch Pathol Lab Med 2003;127:1217)
Gross description
- Unencapsulated, brittle, brown purple, granulation tissue mass
Microscopic (histologic) description
- Fibrillar connective tissue stroma with small oval and spindly mononuclear cells mixed with uneven clusters of multinuclear (5 - 40) giant cells
- Small capillaries, hemorrhage, hemosiderin, reactive bone with osteoblastic rimming
- No pleomorphism, no / rare mitotic figures
Microscopic (histologic) images
Positive stains
- Giant cells - CD68, tartrate resistant acid phosphatase (TRAP), patchy macrophage markers
- Mononuclear cells - Ki67, TRAP
Additional references