Bone & joints

Other tumors

Liposclerosing myxofibrous tumor

Last author update: 1 July 2013
Last staff update: 18 January 2022

Copyright: 2003-2023,, Inc.

PubMed Search: Liposclerosing myxofibrous tumor[title]

Nat Pernick, M.D.
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Cite this page: Pernick N Liposclerosing myxofibrous tumor. website. Accessed September 22nd, 2023.
Definition / general
  • Also called polymorphic fibroosseous tumor of bone
  • Mixture of lipoma, fibroxanthoma, myxoma, myxofibroma, cyst formation, fat necrosis, ischemic ossification and fibrous dysplasia-like features
  • Mean age 40 years but also teens to 60’s
  • Usually incidental findings, but may gradually enlarge causing fracture, or occasionally undergo malignant transformation
  • Sites: 80% involve proximal femur; also ileum, humerus, rib
  • Some of these cases may be a variant of fibrous dysplasia with similar mutations (Hum Pathol 2003;34:1204)
  • 10% have malignant transformation
Radiology description
  • Well-defined, lytic lesion with sclerotic margin, resembling bone infarct
Microscopic (histologic) description
  • Fat, xanthoma cells, cementum-like ossicles, Paget-type bone, myxofibrous tissue with cystic change
  • Curvilinear trabeculae in fibrous tissue in some cases
Additional references
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