Bone marrow nonneoplastic
Infectious / inflammatory

Topic Completed: 1 January 2014

Minor changes: 2 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Candida [title] bone marrow [title]

Dragos C. Luca, M.D.
Page views in 2020: 220
Page views in 2021 to date: 5
Cite this page: Luca DC. Candida. website. Accessed January 22nd, 2021.
Definition / general
  • Fungal infections are rare in bone marrow and peripheral blood and almost exclusively occur in immunocompromised individuals
  • Candida albicans is one of the most common organisms
  • It dominates among patients with liver, kidney or pancreas transplants
  • Candida is also the most common fungal organism in immunocompetent patients with bone marrow granulomas
  • Disseminated candidiasis may be seen in newborns and is frequent in children treated for leukemia
  • Candida infection may promote granulopoiesis (Stem Cells Dev 2004;13:39)
Case reports
Microscopic (histologic) description
  • Typically shows granuloma formation with or without associated central necrosis
  • In patients with underlying immunodeficiency, a diffuse histiocytic hyperplasia without distinct granuloma formation may be seen
  • Organisms are readily identifiable with GMS and PAS
  • In peripheral blood, fungal structures (budding yeasts, pseudohyphae) may be seen within granulocytes and monocytes or extracellularly
Microscopic (histologic) images

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Isolated bone marrow mycosis

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