Bone marrow nonneoplastic


Features to report

Last author update: 1 December 2006
Last staff update: 18 June 2020

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PubMed Search: Bone marrow biopsy [title] report

Nat Pernick, M.D.
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Cite this page: Pernick N Features to report. website. Accessed June 3rd, 2023.
Clinical history
  • Indicate hematologic and other diagnoses and indication for bone marrow
Peripheral blood smear
  • List laboratory data (WBC, Hemoglobin, Hematocrit, MCV, Platelet count, RDW, other)
  • Give microscopic description (number, size, shape, other abnormalities) of red blood cells, white blood cells and platelets
  • Peripheral smear interpretation
Bone marrow biopsy and aspirate
  • Biopsy or aspiration site
  • Cellularity (% and whether hyper, normo or hypocellular for age)
  • Presence or not of trilinear maturation
  • Adequacy of specimen
  • Indicate myeloid: erythroid ratio (M:E ratio), and whether normal, increased or decreased
  • Myeloid cells:
    • Normal or abnormal maturation
    • Indicate if excess blasts
    • Abnormal localization of immature precursors
  • Erythroid cell:
    • Normal or abnormal maturation
  • Provide differential of myeloid and erythroid elements, based on counting 200 - 500 cells in aspirate smear
  • Megakaryocytes:
    • Normal or abnormal numbers and morphology
  • Lymphocytes:
    • Lymphoid aggregates
    • Hematogones
    • Other abnormalities
  • Plasma cells:
    • Normal or increased
    • List abnormalities
  • Histiocytes:
    • Normal or increased
    • List hemophagocytosis or other abnormalities
  • Iron stores:
    • Quantitate (none, 1+, 2+, 3+ or 4+; indicate if normal, increased or decreased)
    • Indicate if ringed sideroblasts are present and how many
  • Fibrosis:
    • Present or not
    • Normal or abnormal
  • Bone:
    • List any abnormalities present
  • Cytogenetic findings
  • Molecular findings
  • Immunohistochemistry findings
  • Other:
    • Presence of metastatic tumor or not
    • Other findings
  • Bone marrow interpretation / diagnosis:
    • Correlate with clinical history
    • Cytogenetics
    • Molecular or immunohistochemistry findings
    • Peripheral blood smear
Mandatory features to report
For accreditation purposes by the American College of Surgeons Committee on Cancer
  • Specimen type
  • Adequacy (adequate, limited, unsatisfactory)
  • Results of special stains or other studies, if performed
  • Results of cytogenetics, if performed
  • Diagnosis (WHO classification)
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