Bone marrow nonneoplastic
General
Features to report
Author: Nat Pernick, M.D.
Last author update: 1 December 2006
Last staff update: 18 June 2020
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Bone marrow biopsy [title] report
Table of Contents
Clinical history | Peripheral blood smear | Bone marrow biopsy and aspirate | Mandatory features to report | Additional referencesCite this page: Pernick N Features to report. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowhowtoexamine.html. Accessed June 3rd, 2023.
Clinical history
- Indicate hematologic and other diagnoses and indication for bone marrow
Peripheral blood smear
- List laboratory data (WBC, Hemoglobin, Hematocrit, MCV, Platelet count, RDW, other)
- Give microscopic description (number, size, shape, other abnormalities) of red blood cells, white blood cells and platelets
- Peripheral smear interpretation
Bone marrow biopsy and aspirate
- Biopsy or aspiration site
- Cellularity (% and whether hyper, normo or hypocellular for age)
- Presence or not of trilinear maturation
- Adequacy of specimen
- Indicate myeloid: erythroid ratio (M:E ratio), and whether normal, increased or decreased
- Myeloid cells:
- Normal or abnormal maturation
- Indicate if excess blasts
- Abnormal localization of immature precursors
- Erythroid cell:
- Normal or abnormal maturation
- Provide differential of myeloid and erythroid elements, based on counting 200 - 500 cells in aspirate smear
- Megakaryocytes:
- Normal or abnormal numbers and morphology
- Lymphocytes:
- Lymphoid aggregates
- Hematogones
- Other abnormalities
- Plasma cells:
- Normal or increased
- List abnormalities
- Histiocytes:
- Normal or increased
- List hemophagocytosis or other abnormalities
- Iron stores:
- Quantitate (none, 1+, 2+, 3+ or 4+; indicate if normal, increased or decreased)
- Indicate if ringed sideroblasts are present and how many
- Fibrosis:
- Present or not
- Normal or abnormal
- Bone:
- List any abnormalities present
- Cytogenetic findings
- Molecular findings
- Immunohistochemistry findings
- Other:
- Presence of metastatic tumor or not
- Other findings
- Bone marrow interpretation / diagnosis:
- Correlate with clinical history
- Cytogenetics
- Molecular or immunohistochemistry findings
- Peripheral blood smear
Mandatory features to report
For accreditation purposes by the American College of Surgeons Committee on Cancer
- Specimen type
- Adequacy (adequate, limited, unsatisfactory)
- Results of special stains or other studies, if performed
- Results of cytogenetics, if performed
- Diagnosis (WHO classification)
Additional references
