Bone marrow nonneoplastic

Storage-type histiocytosis

Sea blue histiocytosis (syndrome)

Last author update: 1 December 2006
Last staff update: 1 September 2021

Copyright: 2002-2019,, Inc.

PubMed Search: Sea blue histiocytosis bone marrow

Nat Pernick, M.D.
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Cite this page: Pernick N. Sea blue histiocytosis (syndrome). website. Accessed May 20th, 2024.
Definition / general
  • Clinical syndrome is associated with splenomegaly, mild thrombocytopenia and bone marrow involvement
  • Many reports using the term "syndrome" are actually reporting just a microscopic finding
  • Microscopic finding is associated with various hematologic and systemic disorders, including:
Case reports
Microscopic (histologic) description
  • Histiocytes have cytoplasm filled with globules / granules of varying size containing blue or blue green pigment (Romanowsky stain) or yellow tan pigment (H&E)
Microscopic (histologic) images

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Chronic myelogenous leukemia

Refractory anemia with excess blasts

Refractory anemia with excess blasts in transformation

Positive stains
Electron microscopy description
  • Myelin figures
Electron microscopy images

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Hyperlipidemia: cytoplasmic electron dense granules

"Finger print" arrangement of membranes

Differential diagnosis
Additional references
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