Bone marrow nonneoplastic
Storage-type histiocytosis
Sea blue histiocytosis (syndrome)
Author: Nat Pernick, M.D.
Last author update: 1 December 2006
Last staff update: 1 September 2021
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Sea blue histiocytosis bone marrow
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy description | Electron microscopy images | Differential diagnosis | Additional referencesCite this page: Pernick N. Sea blue histiocytosis (syndrome). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowseablue.html. Accessed June 3rd, 2023.
Definition / general
- Clinical syndrome is associated with splenomegaly, mild thrombocytopenia and bone marrow involvement
- Many reports using the term "syndrome" are actually reporting just a microscopic finding
- Microscopic finding is associated with various hematologic and systemic disorders, including:
- Niemann-Pick disease (Hum Pathol 1982;13:1115)
- Normal marrow
- Ceroid histiocytosis (Blood 1971;37:587)
- Total parenteral nutrition (Leuk Lymphoma 1998;28:523)
Case reports
- 44 year old man with sea blue histiocytosis secondary to Niemann-Pick disease type B (Ann Hematol 2001;80:620)
Microscopic (histologic) description
- Histiocytes have cytoplasm filled with globules / granules of varying size containing blue or blue green pigment (Romanowsky stain) or yellow tan pigment (H&E)
Microscopic (histologic) images
Images hosted on other servers:
Chronic myelogenous leukemia
Refractory anemia with excess blasts
Refractory anemia with excess blasts in transformation
Positive stains
Electron microscopy description
- Myelin figures
Electron microscopy images
Images hosted on other servers:
Hyperlipidemia: cytoplasmic electron dense granules
"Finger print" arrangement of membranes
Differential diagnosis
Additional references
