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Posttreatment changes associated with various therapies | Changes associated with specific therapies | Microscopic (histologic) images | Additional referencesCite this page: Luca DC. Treatment related changes in bone marrow. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowtreatmentrelated.html. Accessed January 17th, 2021.
Posttreatment changes associated with various therapies
- Bone marrow granulomas
- Sideroblastic anemia
- Metastatic lesion maturation in bone marrow biopsy
- Acute leukemia:
- Initially hypocellular posttreatment with necrosis and proteinaceous debris, dilated sinuses, increased reticulin
- Then regeneration of marrow begins after 1 - 2 weeks
- Other secondary neoplasms: MDS, myeloma, other
Changes associated with specific therapies
- Chloramphenicol, linezolid: vacuolated erythroblasts (Intern Med J 2005;35:626)
- Colchicine therapy: abnormal mitotic figures
- Growth factor therapy: leukemoid reactions
- Immunosuppressive therapy: hemophagocytic syndromes
- Methotrexate and valproic acid: erythroid karyorrhexis, nuclear lobulation, megaloblastic changes
- See also specific disorders