Bone marrow nonneoplastic
Alterations in cellularity
Treatment related changes in bone marrow
Author: Dragos C. Luca, M.D.
Topic Completed: 1 December 2013
Minor changes: 22 July 2019
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Treatment-related changes in bone marrow
Table of Contents
Posttreatment changes associated with various therapies | Changes associated with specific therapies | Microscopic (histologic) images | Additional referencesCite this page: Luca DC. Treatment related changes in bone marrow. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowtreatmentrelated.html. Accessed January 17th, 2021.
Posttreatment changes associated with various therapies
- Bone marrow granulomas
- Sideroblastic anemia
- Metastatic lesion maturation in bone marrow biopsy
- Acute leukemia:
- Initially hypocellular posttreatment with necrosis and proteinaceous debris, dilated sinuses, increased reticulin
- Then regeneration of marrow begins after 1 - 2 weeks
- Other secondary neoplasms: MDS, myeloma, other
Changes associated with specific therapies
- Chloramphenicol, linezolid: vacuolated erythroblasts (Intern Med J 2005;35:626)
- Colchicine therapy: abnormal mitotic figures
- Growth factor therapy: leukemoid reactions
- Immunosuppressive therapy: hemophagocytic syndromes
- Methotrexate and valproic acid: erythroid karyorrhexis, nuclear lobulation, megaloblastic changes
- See also specific disorders
Microscopic (histologic) images
Images hosted on other servers:
Vacuolated erythroblasts
