Bone marrow nonneoplastic

Alterations in cellularity

Treatment related changes in bone marrow

Topic Completed: 1 December 2013

Minor changes: 22 July 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Treatment-related changes in bone marrow

Dragos C. Luca, M.D.
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Cite this page: Luca DC. Treatment related changes in bone marrow. website. Accessed December 3rd, 2021.
Posttreatment changes associated with various therapies
  • Bone marrow granulomas
  • Sideroblastic anemia
  • Metastatic lesion maturation in bone marrow biopsy
  • Acute leukemia:
    • Initially hypocellular posttreatment with necrosis and proteinaceous debris, dilated sinuses, increased reticulin
    • Then regeneration of marrow begins after 1 - 2 weeks
  • Other secondary neoplasms: MDS, myeloma, other
Changes associated with specific therapies
  • Chloramphenicol, linezolid: vacuolated erythroblasts (Intern Med J 2005;35:626)
  • Colchicine therapy: abnormal mitotic figures
  • Growth factor therapy: leukemoid reactions
  • Immunosuppressive therapy: hemophagocytic syndromes
  • Methotrexate and valproic acid: erythroid karyorrhexis, nuclear lobulation, megaloblastic changes
  • See also specific disorders
Microscopic (histologic) images

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Vacuolated erythroblasts

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