Table of Contents
Definition / general | Diagnosis | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy description | Electron microscopy images | Additional referencesCite this page: Pernick N. Whipple disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowwhipple.html. Accessed January 22nd, 2021.
Definition / general
- Chronic inflammatory disease due to Tropheryma whipplei bacteria
- Usually affects small intestine
Diagnosis
- PAS+ foamy macrophages
- Electron microscopy
- PCR
Case reports
- 49 year old with bacteria detected by PCR in bone marrow (Hum Pathol 2004;35:522)
Microscopic (histologic) description
- Noncaseating granulomas
- Numerous foamy macrophages containing PAS+ diastase resistant bacteria
Microscopic (histologic) images
Positive stains
Electron microscopy description
- Bacilli within membrane bound vesicles
Electron microscopy images