Bone marrow nonneoplastic
Infectious / inflammatory
Whipple disease
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2006
Minor changes: 7 August 2019
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Bone marrow Whipple disease
Table of Contents
Definition / general | Diagnosis | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy description | Electron microscopy images | Additional referencesCite this page: Pernick N. Whipple disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowwhipple.html. Accessed March 9th, 2021.
Definition / general
- Chronic inflammatory disease due to Tropheryma whipplei bacteria
- Usually affects small intestine
Diagnosis
- PAS+ foamy macrophages
- Electron microscopy
- PCR
Case reports
- 49 year old with bacteria detected by PCR in bone marrow (Hum Pathol 2004;35:522)
Microscopic (histologic) description
- Noncaseating granulomas
- Numerous foamy macrophages containing PAS+ diastase resistant bacteria
Microscopic (histologic) images
Images hosted on other servers:
PAS staining
PAS, oil immersion
Grocott, oil immersion
Duodenum
Immunofluorescence (blue - bacteria, green - nuclei, red - vimentin)
Lymph node
Positive stains
Electron microscopy description
- Bacilli within membrane bound vesicles
Electron microscopy images
Images hosted on other servers:
Whipple disease, duodenum
T. whipplei bacteria
Bacterium (arrowhead)
