Table of Contents
Definition / general | Radiology description | Treatment | Radiology images | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Stockman DL. Telangiectatic osteosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonetelangosteo.html. Accessed March 4th, 2021.
Definition / general
- 3% of osteosarcomas
- High grade variant of osteosarcoma showing significant cystic change with hemorrhage and necrosis
- Rapid growth of tumor causes tumor necrosis, hemorrhage and cystic cavitation
- Associated with pathologic fractures, dull pain and swelling for a few months duration
Radiology description
- Lesions are extremely lytic and expansile, may suggest aneurysmal bone cyst or hematoma
- Magnetic resonance imaging may show fluid fluid levels, again correlating with aneurysmal bone cyst
Treatment
- Resection and neoadjuvant therapy; protocols same as conventional osteosarcoma
Gross description
- Lobulated expansile tumor occurring predominantly in metaphyseal area with cystic spaces filled with blood and necrosis
Microscopic (histologic) description
- Prominent blood filled cysts separated by septa containing malignant hypercellular and anaplastic stroma
- Demonstrates very little osteoid production
- May form eccentric or circumferential soft tissue component that displaces periosteum peripherally
Microscopic (histologic) images
Differential diagnosis
- Aneurysmal bone cyst: no malignant cells present within septa
- Angiosarcoma