Table of Contents
Definition / general | Radiology description | Treatment | Radiology images | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Stockman DL. Telangiectatic osteosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonetelangosteo.html. Accessed March 4th, 2021.
Definition / general
- 3% of osteosarcomas
- High grade variant of osteosarcoma showing significant cystic change with hemorrhage and necrosis
- Rapid growth of tumor causes tumor necrosis, hemorrhage and cystic cavitation
- Associated with pathologic fractures, dull pain and swelling for a few months duration
Radiology description
- Lesions are extremely lytic and expansile, may suggest aneurysmal bone cyst or hematoma
- Magnetic resonance imaging may show fluid fluid levels, again correlating with aneurysmal bone cyst
Treatment
- Resection and neoadjuvant therapy; protocols same as conventional osteosarcoma
Radiology images
AFIP images
Proximal fibula
Contributed by Dr. Mark R. Wick
Xray
Gross description
- Lobulated expansile tumor occurring predominantly in metaphyseal area with cystic spaces filled with blood and necrosis
Gross images
Contributed by Dr. Mark R. Wick
Various images
Proximal tibia
Microscopic (histologic) description
- Prominent blood filled cysts separated by septa containing malignant hypercellular and anaplastic stroma
- Demonstrates very little osteoid production
- May form eccentric or circumferential soft tissue component that displaces periosteum peripherally
Microscopic (histologic) images
Contributed by Dr. Mark R. Wick
Telangiectatic and small cell
Various images
Various images
AFIP images
Coronal section
Sparse solid areas
Markedly abnormal nuclei
Delicate, calcified osteoid
Differential diagnosis
- Aneurysmal bone cyst: no malignant cells present within septa
- Angiosarcoma
