Other nonneoplastic

Cystic hypersecretory hyperplasia

Last author update: 1 May 2010
Last staff update: 1 April 2021

Copyright: 2002-2023,, Inc.

PubMed Search:: Cystic hypersecretory hyperplasia of breast

Hind Warzecha, M.D.
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Cite this page: Warzecha H. Cystic hypersecretory hyperplasia. website. Accessed September 21st, 2023.
Definition / general
  • Cystically dilated ducts of various sizes with colloid-like material
  • Ducts are lined by flat, orderly, bland columnar epithelial cells
  • Not included in WHO classification of breast lesions
  • Cystic hypersecretory carcinoma: lesions that resemble cystic hypersecretory hyperplasia but with proliferative atypical epithelium
  • Rare
  • Unknown
Clinical features
  • Palpable mass or occasionally asymptomatic with mammographic abnormality
  • Benign lesion with good prognosis when not associated with atypia or carcinoma
Case reports
Gross description
  • Resembles juvenile papillomatosis
  • Large, ill defined, firm to rubbery, spongy mass of fibrous tissue containing multiple small cysts
  • Also abundant thick, sticky mucin within the cysts; resembles thyroid colloid
  • May coexist with atypia or DCIS of cystic hypersecretory type, so sample generously
Microscopic (histologic) description
  • Cystically dilated ducts of various sizes with colloid-like material, often with parallel fracture lines, retraction halo and overlapping due to processing
  • Ducts are lined by flat, orderly, columnar epithelial cells with eosinophilic cytoplasm; nuclei are round / oval, vesicular, bland
  • Atypical features are epithelial crowding, enlarged nuclei lacking normal polarization, hyperchromasia and rare mitotic figures
  • Can be associated with pregnancy-like (pseudolactational) hyperplasia (Am J Surg Pathol 2000;24:1670)
Microscopic (histologic) images

AFIP images

Cysts lined by flat
cuboidal epithelium
contain eosinophilic

Atypia - focal atypical epithelium between cysts

 Case #35

Cysts lined by flat cuboidal epithelium contain eosinophilic material

Intraluminal secretions show
fine, parallel cracks and
shrinkage of the cyst content
with peripheral scalloping

Cytology description
  • Secretory material (same as histology) with isolated or clusters of epithelial cells
Positive stains
  • PR in a small subset
Negative stains
Differential diagnosis
  • Cystic hypersecretory DCIS
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