Foreign body reaction

Topic Completed: 1 April 2010

Minor changes: 16 February 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Breast foreign body [title] reaction

Hind Warzecha, M.D.
Page views in 2020: 3,403
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Cite this page: Warzecha H. Foreign body reaction. website. Accessed October 25th, 2021.
Definition / general
  • Foreign body giant cell inflammation that usually is localized and occurs 1 - 2 weeks after trauma, surgery or radiation
Clinical features
  • Clinically resembles carcinoma due to skin retraction
Case reports
Due to injections:
Gross description
  • Localized to subcutaneous tissue
  • May be nodular, fibrotic, orange brown (due to hemosiderin)
  • Up to 1 cm
Microscopic (histologic) description
  • Not encapsulated
  • Fibrosis, foreign body giant cells, chronic inflammatory cells, fat necrosis, calcification, cholesterol clefts (needle-like empty spaces, due to substances dissolved during processing), hemosiderin
  • May see a foreign body
Microscopic (histologic) images

Contributed by Dr. Saroona Haroon, The Aga Khan University Hospital (Pakistan)

Cholesterol granuloma in 56 year old woman with 4 month history of hard immobile mass of left breast; no history of pus or blood discharge

Images hosted on other servers:

Asteroid body

Granulation tissue


Foreign body reaction
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