Invasive breast carcinoma of no special type and variants

Pleomorphic ductal carcinoma

Topic Completed: 1 August 2012

Minor changes: 5 April 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Pleomorphic carcinoma [title]

Monika Roychowdhury, M.D.
Page views in 2020: 1,345
Page views in 2021 to date: 1,733
Cite this page: Roychowdhury M. Pleomorphic ductal carcinoma. website. Accessed October 16th, 2021.
Definition / general
  • Part of WHO classification
  • Variant of high grade ductal NOS with pleomorphic and bizarre tumor cells comprising 50% or more of tumor cells
Clinical features
  • Aggressive behavior
Case reports
  • 83 year old woman with pleomorphic tumor with predominantly micropapillary features (Pathol Int 2007;57:694)
Microscopic (histologic) description
  • 50%+ of tumor has pleomorphic cell population (> 6X variation in nuclear size) (Histopathology 2000;36:505)
  • Excludes tumors of lobular origin
  • Adjacent DCIS or classic ductal carcinoma in 73%
  • Usually brisk mitotic activity
Microscopic (histologic) images

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Pleomorphic carcinoma of the breast

Positive stains
Negative stains
Differential diagnosis
  • Sarcoma
Additional references
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