Breast

Neuroendocrine carcinoma

Large cell



Topic Completed: 1 August 2012

Minor changes: 19 March 2021

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PubMed Search: Neuroendocrine carcinoma [title] large cell

Monika Roychowdhury, M.D.
Page views in 2020: 851
Page views in 2021 to date: 1,013
Cite this page: Roychowdhury M. Large cell. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/breastmalignantneuroendocrinelargecell.html. Accessed October 25th, 2021.
Definition / general
  • Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+ / 10 HPF)
Terminology
  • Part of WHO classification
Case reports
Treatment
  • Aggressive tumor requiring multimodal treatment
Clinical images

Contributed by Dr. Mark R. Wick

Left lateral MRI

Microscopic (histologic) description
  • Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick

Left lateral



Images hosted on other servers:

Nests of large tumor cells

Chromogranin+

Differential diagnosis
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