CD Markers

Topic Completed: 1 August 2013

Minor changes: 9 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD100[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD100. website. Accessed January 15th, 2021.
Definition / general
  • Also called SEMA4D, semaphorin 4D
  • Integral membrane protein and ligand for CD72 and plexin-B1
  • Functions:
    1. Regulates axonal growth cone guidance in the developing CNS through its receptor plexin-B1, which may be related to its expression in invading islands of transformed epithelial cells (but not normal and noninvasive dysplastic epithelium, Proc Natl Acad Sci USA 2006;103:9017)
    2. Evokes angiogenic responses from endothelial cells (Blood 2005;105:4321)
    3. Impairs monocyte migration
    4. After vascular injury, platelet associated CD100 binds to CD100 receptors on nearby platelets to promote thrombus formation (Proc Natl Acad Sci USA 2007;104:1621)
    5. Increases CD45 induced T cell adhesion
    6. Down regulates B cell expression of CD23
  • Expression may have prognostic value in soft tissue sarcoma (Cancer 2007;110:164)
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

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Head and neck squamous cell carcinoma

Positive staining - normal
  • Most hematopoietic cells including platelets, increased expression after T cell activation
Negative staining
  • Immature bone marrow cells
Additional references
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