CD Markers
CD100
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD100[title]
CD100
Author: Nat Pernick, M.D.
Topic Completed: 1 August 2013
Minor changes: 9 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD100[title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Negative staining | Additional referencesCite this page: Pernick N. CD100. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd100.html. Accessed January 15th, 2021.
Definition / general
- Also called SEMA4D, semaphorin 4D
- Integral membrane protein and ligand for CD72 and plexin-B1
- Functions:
- Regulates axonal growth cone guidance in the developing CNS through its receptor plexin-B1, which may be related to its expression in invading islands of transformed epithelial cells (but not normal and noninvasive dysplastic epithelium, Proc Natl Acad Sci USA 2006;103:9017)
- Evokes angiogenic responses from endothelial cells (Blood 2005;105:4321)
- Impairs monocyte migration
- After vascular injury, platelet associated CD100 binds to CD100 receptors on nearby platelets to promote thrombus formation (Proc Natl Acad Sci USA 2007;104:1621)
- Increases CD45 induced T cell adhesion
- Down regulates B cell expression of CD23
- Expression may have prognostic value in soft tissue sarcoma (Cancer 2007;110:164)
Uses by pathologists
- No significant clinical use by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Head and neck squamous cell carcinoma
Positive staining - normal
- Most hematopoietic cells including platelets, increased expression after T cell activation
Negative staining
- Immature bone marrow cells
Additional references
