CD Markers
CD102
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD102 [title]
CD102
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD102 [title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. CD102. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd102.html. Accessed January 15th, 2021.
Definition / general
- Also called ICAM-2
- Binds the leukocyte integrins LFA-1 (CD11a / CD18) and Mac-1 (CD11b / CD18)
- Provides costimulatory signal in immune response
- Important in lymphocyte recirculation (J Immunol 2003;171:2588)
- Endothelial ICAM-2 mediates angiogenesis (Blood 2005;106:1636)
- Elevated serum levels in:
- Hemorrhagic fever with renal syndrome (Viral Immunol 2006;19:565)
- Idiopathic pulmonary fibrosis (Inflammation 2004;28:359)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Resting lymphocytes, monocytes, platelets, vascular endothelial cells
Positive staining - disease
- Some lymphomas
Negative staining
- Neutrophils
Additional references
