CD Markers
CD103
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD103 [title]
CD103
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD103 [title]
Table of Contents
Definition / general | Uses by pathologists | Molecular / cytogenetics images | Positive staining - normal | Positive staining - disease | Additional referencesCite this page: Pernick N. CD103. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd103.html. Accessed January 16th, 2021.
Definition / general
- Also called human mucosal lymphocyte antigen 1, integrin alpha E beta 7
- CD103+ tumor infiltrating lymphocytes have a cytotoxic antitumor effect (J Exp Med 2007;204:559), may play a role in renal allograft rejection (Am J Transplant 2004;4:1026, J Exp Med 2002;196:873)
Uses by pathologists
- Marker for hairy cell leukemia, intraepithelial lymphocytes (normal or tumor)
Molecular / cytogenetics images
Images hosted on other servers:
Hairy cell leukemia variant often expresses CD103 but not CD25
Positive staining - normal
- Intraepithelial T lymphocytes (90% in GI, tonsil, J Immunol 2005;175:4355, 30% in lung, Clin Exp Immunol 2007;149:162), lamina propria T lymphocytes in the intestine (50%), dendritic cells in gut (J Exp Med 2005;202:1051), rare peripheral blood lymphocytes
Positive staining - disease
- Hairy cell leukemia (usually, Am J Clin Pathol 2006;125:251), enteropathy associated T cell lymphoma, splenic marginal zone lymphoma (some)
Additional references
