CD Markers
CD109
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD109 [title]
CD109
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD109 [title]
Table of Contents
Definition / general | Positive staining - normal | Negative staining | Additional referencesCite this page: Pernick N. CD109. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd109.html. Accessed January 15th, 2021.
Definition / general
- Also called platelet activation factor
- Glycosylphosphatidylinositol-anchored cell surface protein
- Carries the biallelic platelet-specific Gov antigen system
- Alloantibodies to HPA-15 residing on CD109 are implicated in refractoriness to platelet transfusion, fetal / neonatal alloimmune thrombocytopenia and posttransfusion purpura (Blood 2002;99:1692)
Positive staining - normal
- Activation antigen for platelets and T cells
- Subset of hematopoietic stem and progenitor cells (Exp Hematol 1999;27:1282)
- Myoepithelial cells (breast, prostate [basal cells] salivary and lacrimal glands, Pathol Int 2007;57:245)
- Widely expressed in other tissues
Negative staining
- Invasive ductal carcinoma (breast), prostate adenocarcinoma
Additional references
