CD Markers

Topic Completed: 1 February 2002

Minor changes: 9 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD109 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD109. website. Accessed January 15th, 2021.
Definition / general
  • Also called platelet activation factor
  • Glycosylphosphatidylinositol-anchored cell surface protein
  • Carries the biallelic platelet-specific Gov antigen system
    • Alloantibodies to HPA-15 residing on CD109 are implicated in refractoriness to platelet transfusion, fetal / neonatal alloimmune thrombocytopenia and posttransfusion purpura (Blood 2002;99:1692)
Positive staining - normal
  • Activation antigen for platelets and T cells
  • Subset of hematopoietic stem and progenitor cells (Exp Hematol 1999;27:1282)
  • Myoepithelial cells (breast, prostate [basal cells] salivary and lacrimal glands, Pathol Int 2007;57:245)
  • Widely expressed in other tissues
Negative staining
  • Invasive ductal carcinoma (breast), prostate adenocarcinoma
Additional references
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