Cite this page: Pernick N. CD11. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd11.html. Accessed May 8th, 2021.
Definition / general
- Alpha component of various integrins (CD11a, CD11b, CD11c, CD11d)
- Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain
- Adhesion molecules of the beta2 integrin family (CD11 / CD18) plays an essential role in neutrophil recruitment and activation during inflammation
Clinical features
- Deficiency of CD18 component (leukocyte adhesion deficiency) is a rare, inherited disorder, causing recurrent severe bacterial infections early in life, possibly fatal (OMIM #116920, Hematol Oncol Clin North Am 1988;2:13)
