CD Markers
CD110-119


Topic Completed: 1 February 2002

Minor changes: 14 May 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD110 [title], CD111[title], CD112[title], nectin-3[title], CD114[title], CD115[title], CD116[title], CD118[title], CDw119[title]

Nat Pernick, M.D.
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Table of Contents
CD110 | CD111 | CD112 | CD113 | CD114 | CD115 | CD116 | CD117 | CD118 | CDw119
Cite this page: Pernick N. CD110-119. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd110.html. Accessed June 20th, 2021.
CD110

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CD110: protein and site, various mutations

CD111
  • Also known as poliovirus receptor related 1 (PRR1), nectin1
  • Widely expressed adhesion molecule that is a component of the adherens junction; receptor for herpes simplex viruses 1 and 2
  • Positive staining - normal: cells from myeloid, monocyte, megakaryocytes and erythroid lineage, epithelial cells, neurons, endothelium
CD112
  • Also known as poliovirus receptor related 2 (PRR2)
  • Adhesion molecule that is a component of the adherens junction; receptor for herpes simplex virus
  • Positive staining - normal: cells from myeloid, monocyte, megakaryocytes lineage, epithelial cells, neurons, endothelium
CD113
  • Also called nectin3, poliovirus receptor related protein 3 precursor
CD114
  • Also known as granulocyte colony stimulating factor receptor, G-CSFR
  • Specific regulator of myeloid proliferation and differentiation
  • Mutations present in some patients with severe congenital neutropenia
  • Positive staining - normal: granulocytes (all), monocytes, platelets, endothelium, placenta, trophoblastic cells
  • Positive staining - malignant: cultured tumor cells
  • Negative staining: eosinophils, lymphocytes, erythrocytes
CD115
  • Also known as c-fms, receptor for macrophage colony stimulating factor, CSF-1R
  • Localized on cytoplasmic membrane; mediates biologic activity of CSF-1
  • v-fms is a viral oncogene present in the feline McDonough sarcoma virus (has several substitute mutations)
  • Related to platelet derived growth factor receptor, c-kit, vascular endothelial growth factor receptor, fibroblast growth factor receptor, high affinity nerve growth factor (TrkA)
  • Deficiency causes reduced osteoclasts and macrophages, abnormal bone remodeling and osteopetrosis, abnormal breast development and decreased fertility
  • Positive staining - normal: macrophages and precursors, osteoclasts, placental trophoblast, breast tissue, microglia, neurons, astrocytes
  • Positive staining - malignant: 10% AML, some endometrial, ovarian and breast cancers, vascular smooth muscle cells in atheromas, choriocarcinoma cells
CD116
  • GM-CSF receptor alpha chain
  • Primary binding subunit of GM-CSF receptor
  • Positive staining - normal: monocytes, neutrophils, eosinophils, fibroblasts, endothelial cells, dendritic cells
CD117
CD118
  • Reserved for interferon alpha / gamma receptor
CDw119
  • Interferon gamma receptor
  • Positive staining - normal: macrophages, B cells
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