CD Markers
CD115
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD115[title]
CD115
Author: Nat Pernick, M.D.
Topic Completed: 1 August 2013
Minor changes: 9 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD115[title]
Cite this page: Pernick N. CD115. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd115.html. Accessed January 16th, 2021.
Definition / general
- Aka c-fms, receptor for macrophage colony stimulating factor, CSF-1R
- Localized on cytoplasmic membrane; mediates biologic activity of CSF-1
- v-fms is a viral oncogene present in the feline McDonough sarcoma virus (has several substitute mutations)
- Related to platelet derived growth factor receptor, c-kit, vascular endothelial growth factor receptor, fibroblast growth factor receptor, high affinity nerve growth factor (TrkA)
- Deficiency causes reduced osteoclasts and macrophages, abnormal bone remodeling and osteopetrosis, abnormal breast development and decreased fertility
Positive staining - normal
- Macrophages and precursors, osteoclasts, placental trophoblast, breast tissue, microglia, neurons, astrocytes
Positive staining - malignant
- 10% AML, some endometrial, ovarian and breast cancers, vascular smooth muscle cells in atheromas, choriocarcinoma cells
