CD Markers

Topic Completed: 2 September 2013

Minor changes: 1 October 2020

Copyright: 2012-2021,, Inc.

PubMed Search: CD11a

Related topics: CD11, CD11b, CD11c, CD11d

Nat Pernick, M.D.
Page views in 2020: 208
Page views in 2021 to date: 9
Cite this page: Pernick, N. CD11a. website. Accessed January 15th, 2021.
Definition / general
  • Alpha integrin chain at 16p11-13.1 that binds to CD18 and has various leukocyte functions (OMIM #153370)
  • Also called integrin alpha L, ITGAL and LFA1 alpha chain (in complex with CD18)
  • Alpha integrin chain which binds to CD18 and mediates leukocyte adhesion to endothelium, leukocyte trafficking through activated endothelium, lymphocyte blastogenesis, lymphocyte-endothelial cell adhesion, lymphocyte recirculation through lymph nodes, cytotoxic T cell mediated killing and antibody dependent killing by neutrophils and monocytes
  • Also mediates binding to unopsonized bacteria (e.g. E. coli) and fungi (e.g. Histoplasma capsulatum)
  • With CD18, binds to ICAM1 (CD54), ICAM2 (CD102), ICAM3 (CD50) and ICAM4 (CD242)
  • CD11a identifies effector and memory CD8+ T cells, independent of antigen specificity (Oncoimmunology 2013;2:e23972)
  • Decreased levels in CD4+ T cells in infants with biliary atresia, due to hypermethylation of CD11a promoter region (Biochem Biophys Res Commun 2012;417:986)
  • Increased levels in CD4+ T cells with immune thrombocytopenia (ITP, J Clin Immunol 2011;31:632)
Clinical features
Uses by pathologists
  • CD11a deficiency during flow cytometry useful to diagnose acute promyelocytic leukemia (Am J Clin Pathol 2012;138:744)
  • CD11a deficiency during flow cytometry useful to diagnose AML-M7, Down syndrome related AML and transient myeloproliferative disease in children with and without Down syndrome (Cytometry B Clin Cytom 2013;84:370)
Microscopic (histologic) images

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Intestinal mucosa (fig F)

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Eruptive papules with efalizumab therapy

Positive staining - normal
  • All leukocytes
Positive staining - disease
Negative staining
  • Platelets, various intermediate and high grade lymphomas
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