CD Markers

Topic Completed: 2 September 2013

Minor changes: 1 October 2020

Copyright: 2012-2021,, Inc.

PubMed Search: CD11b

Related topics: CD11, CD11a, CD11c, CD11d

Nat Pernick, M.D.
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Cite this page: Pernick, N. CD11b. website. Accessed March 2nd, 2021.
Definition / general
  • Alpha component of an integrin at 16p11-13.1 that mediates adhesion (OMIM #120980)
  • Also called integrin alpha M, Mac-1 and CR3A
  • Mediates monocyte / macrophage / granulocyte adhesion to substrates by opsonization with iC3b, leading to phagocytosis, neutrophil aggregation and chemotaxis
  • Ligands include fibrinogen, Factor X, ICAM1, iC3b, Saccharomyces cerevisiae, Staphylococcus epidermidis and Histoplasma capsulatum
  • Expression is associated with activation of T cells
Clinical features
Uses by pathologists
  • Common myeloid marker and NK (natural killer cell) antigen
  • Differentiates recovery from acute agranulocytosis (CD11b+, CD117-) from acute promyelocytic leukemia (CD11b-, CD117+, Am J Clin Pathol 2002;118:31)
  • Differentiates Down syndrome patients with AML (usually CD13+, CD11b+) from transient myeloproliferative disorder (usually CD13-, CD11b-, Am J Clin Pathol 2001;116:204)
  • May be useful for flow cytometry diagnosis of myelodysplastic syndrome as part of panel (Ann Clin Lab Sci 2012;42:271)
Microscopic (histologic) images

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Spleen - normal

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Gastric cancer

Positive staining - normal
  • Granulocytes, macrophages
  • Follicular dendritic cells, myeloid cells beginning with promyelocytes, NK cells, some B/T cells
Positive staining - disease
Negative staining
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