CD Markers
CD11c
CD11c
Table of Contents
Definition / general | Pathophysiology | Clinical features | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick, N. CD11c. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd11c.html. Accessed January 16th, 2021.
Definition / general
- Integrin at 16p11-13.1 that acts as a fibrinogen receptor, and is important in monocyte adhesion and chemotaxis (OMIM #151510)
- Also called integrin alpha X, CR4 and LeuM5
Pathophysiology
- Clears opsonized particles and immune complexes
- Also binds to fibrinogen and is involved in adhesion of monocytes and neutrophils to endothelium and chemotaxis
- CD11c+ CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity (Diabetes 2010;59:1648)
Clinical features
- Associated with good prognosis in B-CLL
- High expression in polycystic ovary syndrome (Eur J Endocrinol 2012;167:705)
Uses by pathologists
- Marker of histiocytes, NK cells
- Used to diagnose hairy cell leukemia (with other markers)
Microscopic (histologic) images
Contributed by Leica Microsystems
Hairy cell leukemia
Positive staining - normal
- Granulocytes, macrophages, NK cells, dendritic cells (PLoS One 2012;7:e33556)
- 50% of activated CD4 / CD8+ T cells
Positive staining - disease
- Hairy cell leukemia (classic and variant, Am J Clin Pathol 1991;96:100)
- AML-M4 and M5 (50%), follicular lymphoma (some), Langerhans cell histiocytosis, lymphoplasmacytic lymphoma (81%, Am J Clin Pathol 2005;124:414), psoriatic skin lesions (Proc Natl Acad Sci USA 2005;102:19057), sinus histiocytosis with massive lymphadenopathy (Hum Pathol 1992;23:647), small lymphocytic lymphoma (Am J Clin Pathol 1998;110:582), splenic lymphoma with villous lymphocytes (Am J Clin Pathol 1988;90:250)
Negative staining
- Mantle cell lymphoma (Am J Clin Pathol 2010;134:271), AML-M3 (Am J Clin Pathol 1998;109:211), splenic and non-splenic marginal zone lymphoma (Am J Clin Pathol 1996;105:277)
