Stains & CD markers
CD120-129


Topic Completed: 1 August 2013

Minor changes: 24 June 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: tnfr1[title], CD121a OR CDw121b, CD122, CD123[title], CD124, IL5RA[title], IL5RA[title], CD126[title], CD127[title], CD129

Nat Pernick, M.D.
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Table of Contents
CD120 | CD121a | CDw121b | CD122 | CD123 | CD124 | CDw125 | CD126 | CD127 | CD128 | CD129
Cite this page: Pernick N. CD120-129. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd120.html. Accessed October 24th, 2021.
CD120
  • CD120a: aka TNFR1, receptor for tumor necrosis factor alpha and beta, type I; receptor binding to ligand causes apoptosis
  • CD120b: aka receptor for tumor necrosis factor (TNF) alpha and beta, type II
CD121a
  • Also known as Interleukin 1 receptor (IL-1R) type I, IL1-alpha
  • Interleukin-1, an inflammatory mediator, consists of 2 separate but related proteins, IL1-alpha and IL1-beta
  • Positive staining - normal: T cells, thymocytes, fibroblasts, endothelial cells
CDw121b
  • Also known as Interleukin 1 receptor (IL-1 R) type II, IL1-beta
  • May inhibit IL1 activity by acting as a decoy target for IL1
  • Positive staining - normal: B cells, macrophages
CD122
  • Aka Interleukin 2 receptor beta chain (IL-2R beta)
  • Critical component of IL-2 and IL-15-mediated signaling
  • Positive staining - normal: NK cells, B cells, T cells, monocytes
CD123
CD124
  • Aka Interleukin 4 receptor
  • Receptor subunit for Interleukin-4 and 13
  • Positive staining - normal: mature B cells, T cells; hematopoietic precursors; fibroblasts, endothelial cells
CDw125
  • Aka Interleukin 5 receptor alpha subunit (IL5RA)
  • Therapeutic target of eosinophilic inflammation involved in bronchial asthma
  • Positive staining - normal: eosinophils, activated B cells, basophils
CD126
  • Aka Interleukin 6 receptor
  • Continuous expression of IL-6 and CD130, ligands for CD126, causes hypergammaglobulinemia, glomeruloproliferative nephritis and lymphoid infiltration in some organs
  • Dysregulated stimulation may cause myeloma and plasmacytoma
  • Positive staining - normal: T cells, monocytes, activated B cells, hepatocytes
CD127
  • Aka Interleukin 7 receptor
  • Positive staining - normal: B cell precursors, most T cells, monocytes
CD128
CD129
  • Reserved for Interleukin 9 receptor
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