Stains & CD markers
CD130-139


Topic Completed: 1 February 2002

Minor changes: 24 June 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD130[title], CSF2RB[title], CD132[title], CD133[title], CD134[title], FLT3 CD135, CDw136, CDw137[title], CD139[title]

Nat Pernick, M.D.
Page views in 2020: 55
Page views in 2021 to date: 1,232
Table of Contents
CD130 | CDw131 | CD132 | CD133 | CD134 | FLT3 / CD135 | CDw136 | CDw137 | CD138 | CD139
Cite this page: Pernick N. CD130-139. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd130.html. Accessed October 24th, 2021.
CD130
  • Aka gp 130
  • Required for transducing biological activities of IL6, IL11, leukemia inhibitory factor, ciliary neurotrophic factor, oncostatin M and cardiotrophin-1
  • IL6 and oncostatin M dependent activation of gp130 are involved in multiple myeloma
  • Positive staining - normal: almost all cell types (low levels)
CDw131
  • Aka common beta subunit
  • Does not bind any cytokine by itself, but is a component of the high affinity IL-3, GM-CSF and IL-5 receptors
  • Defective CDw131 is associated with protein alveolar proteinosis
  • Positive staining - normal: myeloid (early and mature), early B cells
CD132
  • Aka common cytokine receptor gamma chain - receptor for IL-2, IL-4, IL-7, IL-9 and IL-15
  • Mutation in humans causes X-linked severe combined immunodeficiency (no T cells, no NK cells)
  • CD132 is a target molecule for gene therapy for X-SCID
  • Positive staining - normal: T cells, B cells, NK cells, monocytes / macrophages, neutrophils
CD133
  • Also known as Prominin 1, AC133
  • Transmembrane glycoprotein expressed on the hematopoietic stem cells, endothelial progenitors and dermal derived stem cells capable of differentiating into neural cells
  • Uses by pathologists: alternative to CD34 in selecting hematopoietic stem and progenitor cells for transplantation studies; marker of cancer stem cells (cells with tumor initiating potential) (Genes Chromosomes Cancer 2012;51:792)
  • Clinical features:
  • Positive staining - normal:
    • Localized to microvilli and other plasma membrane protrusions
    • CD34 bright hematopoietic stem and progenitor cells (umbilical cord blood-derived CD133+ cells can differentiate into endothelial cells and induce new blood vessel growth) (Front Biosci 2012;17:2247)
    • Progenitor cells within nephron (Expert Opin Ther Targets 2012;16:157)
    • Neural stem cells and other primitive cells such as retina
    • Villous and extravillous cytotrophoblast, syncytiotrophoblast
  • Positive staining - disease:
    • Numerous malignancies
    • Brain tumors (CD133+ cells have characteristics of endothelial progenitor cells) (Cancer Lett 2012;324:221)
  • Negative staining: adult epithelial tissue, villous stroma

Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Glial tumors

Missing Image

Hepatocellular carcinoma

Missing Image Missing Image

Pancreas - normal

Missing Image

Stomach: gastric carcinoma


Missing Image Missing Image

Colorectal carcinoma

CD134
  • Aka tax-transcriptionally activated glycoprotein 1 receptor, OX40 antigen, lymphoid activation antigen
FLT3 / CD135

Diagrams / tables

Images hosted on other servers:
Missing Image Missing Image

Structure and function

CDw136
  • Aka macrophage stimulating protein receptor, msp receptor
  • May regulate ciliary beat frequency in epithelial cells
  • Positive staining - normal: skin, kidney, lung, liver, intestine and colon
CDw137
  • Costimulator of T cell proliferation
  • Positive staining - normal: T cells, especially CD45RA and CD45R0; also B cells, monocytes, epithelial cells
CD138
CD139
  • Positive staining - normal: B cells, monocytes, granulocytes, erythrocytes (weak), dendritic cells, glomeruli
  • Negative staining: T cells
Back to top
Image 01 Image 02