Table of Contents
CD130 | CDw131 | CD132 | CD133 | CD134 | FLT3 / CD135 | CDw136 | CDw137 | CD138 | CD139Cite this page: Pernick N. CD130-139. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd130.html. Accessed June 2nd, 2023.
CD130
- Aka gp 130
- Required for transducing biological activities of IL6, IL11, leukemia inhibitory factor, ciliary neurotrophic factor, oncostatin M and cardiotrophin-1
- IL6 and oncostatin M dependent activation of gp130 are involved in multiple myeloma
- Positive staining - normal: almost all cell types (low levels)
CDw131
CD132
- Aka common cytokine receptor gamma chain - receptor for IL-2, IL-4, IL-7, IL-9 and IL-15
- Mutation in humans causes X-linked severe combined immunodeficiency (no T cells, no NK cells)
- CD132 is a target molecule for gene therapy for X-SCID
- Positive staining - normal: T cells, B cells, NK cells, monocytes / macrophages, neutrophils
CD133
- Also known as Prominin 1, AC133
- Transmembrane glycoprotein expressed on the hematopoietic stem cells, endothelial progenitors and dermal derived stem cells capable of differentiating into neural cells
- Uses by pathologists: alternative to CD34 in selecting hematopoietic stem and progenitor cells for transplantation studies; marker of cancer stem cells (cells with tumor initiating potential) (Genes Chromosomes Cancer 2012;51:792)
- Clinical features:
- High expression is a poor prognostic factor in:
- Colorectal carcinoma (Mod Pathol 2010;23:450)
- Endometrial carcinoma (Hum Pathol 2010;41:1516)
- Hepatocellular carcinoma (Br J Cancer 2012;106:1997)
- Melanoma (childhood) (Mod Pathol 2010;23:376)
- Neuroblastoma (Histopathology 2012;60:1144)
- Ovarian carcinoma (Mod Pathol 2012;25:456)
- Note: for colorectal carcinoma, CD133 expression may be related to mutation or activity status of Ras-Raf pathway (Clin Cancer Res 2012;18:3132)
- High expression is a poor prognostic factor in:
- Positive staining - normal:
- Localized to microvilli and other plasma membrane protrusions
- CD34 bright hematopoietic stem and progenitor cells (umbilical cord blood-derived CD133+ cells can differentiate into endothelial cells and induce new blood vessel growth) (Front Biosci 2012;17:2247)
- Progenitor cells within nephron (Expert Opin Ther Targets 2012;16:157)
- Neural stem cells and other primitive cells such as retina
- Villous and extravillous cytotrophoblast, syncytiotrophoblast
- Positive staining - disease:
- Numerous malignancies
- Brain tumors (CD133+ cells have characteristics of endothelial progenitor cells) (Cancer Lett 2012;324:221)
- Negative staining: adult epithelial tissue, villous stroma
Microscopic (histologic) images
Images hosted on other servers:
CD134
FLT3 / CD135
- Also known as FMS-like tyrosine kinase 3, CD135
- Class III receptor tyrosine kinase that regulates hematopoiesis (US National Library of Medicine)
- Constitutive activation occurs by internal tandem duplication (ITD) (Arch Pathol Lab Med 2012;136:84); detection fast and inexpensive
- Most frequent molecular abnormality in AML
- Mutated in 10% with chronic myeloproliferative diseases (CMPD) or CMPD/myelodysplastic syndrome but not CML (Am J Clin Pathol 2006;126:530)
- Mutated in 2% with myelodysplastic syndrome (Am J Clin Pathol 2011;135:62)
- Immunophenotypic profile of TdT+ CD7+ CD13+ CD34+ CD117 (bright) predicts FLT3 mutations (100% sensitive, 94% specific) (Am J Clin Pathol 2012;137:213)
- Activated FLT3 inhibited by Sunitinib malate
- Uses by pathologists: subtype of AML (see AML with FLT3 mutations); associated with poor clinical outcome; FLT3 mutations in AML may be unstable (Mod Pathol 2012;25:1405)
Diagrams / tables
Images hosted on other servers:
CDw136
CDw137
CD138
- See CD138