Pathology Outlines

CD Markers
CD130-139

Topic Completed: 1 February 2002

Minor changes: 14 May 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD130[title], CSF2RB[title], CD132[title], CD133[title], CD134[title], FLT3 CD135, CDw136, CDw137[title], CD139[title]

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Table of Contents

CD130 | CDw131 | CD132 | CD133 | CD134 | FLT3 / CD135 | CDw136 | CDw137 | CD138 | CD139

Cite this page: Pernick N. CD130-139. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd130.html. Accessed June 23rd, 2021.

CD130

Aka gp 130
Required for transducing biological activities of IL6, IL11, leukemia inhibitory factor, ciliary neurotrophic factor, oncostatin M and cardiotrophin-1
IL6 and oncostatin M dependent activation of gp130 are involved in multiple myeloma
Positive staining - normal: almost all cell types (low levels)

CDw131

Aka common beta subunit
Does not bind any cytokine by itself, but is a component of the high affinity IL-3, GM-CSF and IL-5 receptors
Defective CDw131 is associated with protein alveolar proteinosis
Positive staining - normal: myeloid (early and mature), early B cells

CD132

Aka common cytokine receptor gamma chain - receptor for IL-2, IL-4, IL-7, IL-9 and IL-15
Mutation in humans causes X-linked severe combined immunodeficiency (no T cells, no NK cells)
CD132 is a target molecule for gene therapy for X-SCID
Positive staining - normal: T cells, B cells, NK cells, monocytes / macrophages, neutrophils

CD133

Also known as Prominin 1, AC133
Transmembrane glycoprotein expressed on the hematopoietic stem cells, endothelial progenitors and dermal derived stem cells capable of differentiating into neural cells
Uses by pathologists: alternative to CD34 in selecting hematopoietic stem and progenitor cells for transplantation studies; marker of cancer stem cells (cells with tumor initiating potential) (Genes Chromosomes Cancer 2012;51:792)
Clinical features:
- High expression is a poor prognostic factor in:
  - Colorectal carcinoma (Mod Pathol 2010;23:450)
  - Endometrial carcinoma (Hum Pathol 2010;41:1516)
  - Hepatocellular carcinoma (Br J Cancer 2012;106:1997)
  - Melanoma (childhood) (Mod Pathol 2010;23:376)
  - Neuroblastoma (Histopathology 2012;60:1144)
  - Ovarian carcinoma (Mod Pathol 2012;25:456)
- Note: for colorectal carcinoma, CD133 expression may be related to mutation or activity status of Ras-Raf pathway (Clin Cancer Res 2012;18:3132)
Positive staining - normal:
- Localized to microvilli and other plasma membrane protrusions
- CD34 bright hematopoietic stem and progenitor cells (umbilical cord blood-derived CD133+ cells can differentiate into endothelial cells and induce new blood vessel growth) (Front Biosci 2012;17:2247)
- Progenitor cells within nephron (Expert Opin Ther Targets 2012;16:157)
- Neural stem cells and other primitive cells such as retina
- Villous and extravillous cytotrophoblast, syncytiotrophoblast
Positive staining - disease:
- Numerous malignancies
- Brain tumors (CD133+ cells have characteristics of endothelial progenitor cells) (Cancer Lett 2012;324:221)
Negative staining: adult epithelial tissue, villous stroma

Microscopic (histologic) images

Images hosted on other servers:

Glial tumors

Hepatocellular carcinoma

Pancreas - normal

Stomach: gastric carcinoma

Colorectal carcinoma

CD134

Aka tax-transcriptionally activated glycoprotein 1 receptor, OX40 antigen, lymphoid activation antigen

FLT3 / CD135

Also known as FMS-like tyrosine kinase 3, CD135
Class III receptor tyrosine kinase that regulates hematopoiesis (US National Library of Medicine)
Constitutive activation occurs by internal tandem duplication (ITD) (Arch Pathol Lab Med 2012;136:84); detection fast and inexpensive
Most frequent molecular abnormality in AML
Mutated in 10% with chronic myeloproliferative diseases (CMPD) or CMPD/myelodysplastic syndrome but not CML (Am J Clin Pathol 2006;126:530)
Mutated in 2% with myelodysplastic syndrome (Am J Clin Pathol 2011;135:62)
Immunophenotypic profile of TdT+ CD7+ CD13+ CD34+ CD117 (bright) predicts FLT3 mutations (100% sensitive, 94% specific) (Am J Clin Pathol 2012;137:213)
Activated FLT3 inhibited by Sunitinib malate
Uses by pathologists: subtype of AML (see AML with FLT3 mutations); associated with poor clinical outcome; FLT3 mutations in AML may be unstable (Mod Pathol 2012;25:1405)

Diagrams / tables

Images hosted on other servers:

Structure and function

CDw136

Aka macrophage stimulating protein receptor, msp receptor
May regulate ciliary beat frequency in epithelial cells
Positive staining - normal: skin, kidney, lung, liver, intestine and colon

CDw137

Costimulator of T cell proliferation
Positive staining - normal: T cells, especially CD45RA and CD45R0; also B cells, monocytes, epithelial cells

CD138

See CD138

CD139

Positive staining - normal: B cells, monocytes, granulocytes, erythrocytes (weak), dendritic cells, glomeruli
Negative staining: T cells