CD Markers

Topic Completed: 1 June 2012

Minor changes: 9 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD133[title]

Nat Pernick, M.D.
Page views in 2020: 214
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Cite this page: Pernick N. CD133. website. Accessed January 15th, 2021.
Definition / general
  • Also known as Prominin 1, AC133
  • Transmembrane glycoprotein expressed on the hematopoietic stem cells, endothelial progenitors, and dermal-derived stem cells capable of differentiating into neural cells
Uses by pathologists
  • Alternative to CD34 in selecting hematopoietic stem and progenitor cells for transplantation studies
  • Marker of cancer stem cells (cells with tumor initiating potential, Genes Chromosomes Cancer 2012;51:792
Clinical features
Microscopic (histologic) images

Images hosted on other servers:
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Glial tumors

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(Fig 3) Hepatocellular carcinoma

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Pancreas - normal

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Stomach - gastric carcinoma

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Colorectal carcinoma

Positive staining - normal
  • Localized to microvilli and other plasma membrane protrusions
  • CD34 bright hematopoietic stem and progenitor cells (umbilical cord blood-derived CD133+ cells can differentiate into endothelial cells and induce new blood vessel growth, Front Biosci 2012;17:2247)
  • Progenitor cells within nephron (Expert Opin Ther Targets 2012;16:157)
  • Neural stem cells and other primitive cells such as retina
  • Villous and extravillous cytotrophoblast, syncytiotrophoblast
Positive staining - disease
  • Numerous malignancies
  • Brain tumors (CD133+ cells have characteristics of endothelial progenitor cells, Cancer Lett 2012;324:221)
Negative staining
  • Adult epithelial tissue, villous stroma
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