CD Markers
CD133
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD133[title]
CD133
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2012
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD133[title]
Table of Contents
Definition / general | Uses by pathologists | Clinical features | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD133. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd133.html. Accessed January 15th, 2021.
Definition / general
- Also known as Prominin 1, AC133
- Transmembrane glycoprotein expressed on the hematopoietic stem cells, endothelial progenitors, and dermal-derived stem cells capable of differentiating into neural cells
Uses by pathologists
- Alternative to CD34 in selecting hematopoietic stem and progenitor cells for transplantation studies
- Marker of cancer stem cells (cells with tumor initiating potential, Genes Chromosomes Cancer 2012;51:792
Clinical features
- High expression is a poor prognostic factor in: colorectal carcinoma (Mod Pathol 2010;23:450), endometrial carcinoma (Hum Pathol 2010;41:1516), hepatocellular carcinoma (Br J Cancer 2012;106:1997), melanoma-childhood (Mod Pathol 2010;23:376), neuroblastoma (Histopathology 2012;60:1144), ovarian carcinoma (Mod Pathol 2012;25:456)
- Note: for colorectal carcinoma, CD133 expression may be related to mutation or activity status of Ras-Raf pathway (Clin Cancer Res 2012;18:3132)
Microscopic (histologic) images
Images hosted on other servers:
Glial tumors
(Fig 3) Hepatocellular carcinoma
Pancreas - normal
Stomach - gastric carcinoma
Colorectal carcinoma
Positive staining - normal
- Localized to microvilli and other plasma membrane protrusions
- CD34 bright hematopoietic stem and progenitor cells (umbilical cord blood-derived CD133+ cells can differentiate into endothelial cells and induce new blood vessel growth, Front Biosci 2012;17:2247)
- Progenitor cells within nephron (Expert Opin Ther Targets 2012;16:157)
- Neural stem cells and other primitive cells such as retina
- Villous and extravillous cytotrophoblast, syncytiotrophoblast
Positive staining - disease
- Numerous malignancies
- Brain tumors (CD133+ cells have characteristics of endothelial progenitor cells, Cancer Lett 2012;324:221)
Negative staining
- Adult epithelial tissue, villous stroma
