Stains & CD markers
CD140-149



Topic Completed: 1 February 2002

Minor changes: 24 June 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: platelet derived growth factor receptor[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD140-149. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd140.html. Accessed July 31st, 2021.
CD140
  • CD140a: also known as alpha platelet derived growth factor receptor
  • CD140b: also known as beta platelet derived growth factor receptor
CD141 (Thrombomodulin)
CD142
  • Aka coagulation Factor III, thromboplastin, tissue factor
  • Major initiator of clotting in normal hemostasis and many thrombotic diseases, via complex with factor VIIa
  • Also binds zymogen factor VII, the inactive precursor form; once bound, a variety of serine proteases rapidly activate factor VII to VIIa via limited proteolysis
  • Normally absent from all cells in direct contact with plasma
  • Positive staining - normal: epidermal keratinocytes, glomerular epithelial cells and various other epithelia, adventitial cells of blood vessels, astrocytes, myocardium, Schwann cells, stromal cells of liver, pancreas, spleen and thyroid
CD143
  • Aka angiotensin-converting enzyme, ACE, peptidyl dipeptidase A
  • Involved in metabolism of angiotensin II and bradykinin; also cleaves substance P and LH-RH
  • Patients with high activity have DD genotype, associated with MI, strokes, diabetic nephropathy
  • Necessary for spermatozoa to bind to egg and associated with better penetration of egg
  • Positive staining - normal: endothelial cells of small/medium arteries, lung capillary endothelium, proximal renal tubule brush borders, basal ganglia neuropil, granulosa cells, Leydig cells, variable on other cells
CD144
  • Endothelial-specific cadherin localized at intercellular junctions
  • Aka vascular endothelial-cadherin precursor, VE-cadherin, cadherin 5
  • Cadherins are cell adhesion proteins that preferentially interact with themselves in a homophilic manner in connecting cells, thus contributing to the sorting of heterogeneous cell types
  • Positive staining - normal: endothelial cells, brain
CDw145
  • Endothelium cell marker
  • Minimal information present as of 1Dec11
  • Note: one paper indicates CD145 is equivalent to CD40L (Rev Clin Esp 2007;207:418), but this appears to be a typo; CD154 is equivalent to CD40L
  • Positive staining - normal: endothelium; basement membrane of Bowman's membrane and tonsillar epithelium (CDw145 Worksheet Panel report-broken link)
CD146
  • Aka melanoma cell adhesion molecule (MEL-CAM), cell surface glycoprotein MUC18
  • May be a neural crest cell adhesion molecule during embryogenesis
  • Associated with tumor progression and the development of metastasis in human malignant melanoma
  • Sensitive but nonspecific marker of desmoplastic/spindle cell melanoma; use if suggestive histology, S100 positive, melanoma markers otherwise negative (Am J Surg Pathol 2001;25:58)
  • Interpretation: membranous staining
  • Positive staining - normal: vascular smooth muscle, endothelium, intermediate trophoblast in exaggerated placental sites and placental site trophoblastic tumors (Hum Pathol 1999;30:687), subpopulation of T cells, endothelium, smooth muscle, Schwann cells
  • Positive staining - malignant
    • Clear cell sarcoma (90%)
    • Leiomyosarcomas (almost all)
    • Melanoma (desmoplastic-84%, epithelioid melanomas-100%, advanced primary tumors and metastatic tumors)
    • Melanotic schwannoma (100%)
    • MPNST (27%), neurofibroma (40%)
    • Prostatic adenocarcinoma and high grade PIN
    • Squamous cell carcinomas (some)
    • Vascular sarcomas (almost all)
  • Negative staining: normal melanocytes, melanocytic nevi, cellular blue nevus, thin primary melanomas, placental site nodules (or focal), epithelioid trophoblastic tumors (or focal), cytotrophoblast, atypical fibroxanthoma
CD147
  • Aka neurothelin, extracellular matrix metalloproteinase inducer
  • Positive staining - normal: all leukocytes, red blood cells, platelets and endothelial cells
CD148
  • Aka HPTP-eta
  • May be involved in contact inhibition of cell growth
  • Positive staining - normal: eranulocytes, monocytes, memory T cells, dendritic cells, platelets, fibroblasts, neurons, Kupffer cells
CD149
  • CDw149 antibodies actually recognize a subset of CD47, also known as integrin-associated protein (IAP), present on leukocytes but not erythrocytes (Tissue Antigens 2000 ;56:258)
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