CD Markers
CD142


Topic Completed: 1 August 2013

Minor changes: 9 October 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: CD142[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD142. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd142.html. Accessed January 15th, 2021.
Definition / general
  • Aka coagulation Factor III, thromboplastin, tissue factor
  • Major initiator of clotting in normal hemostasis and many thrombotic diseases, via complex with factor VIIa
  • Also binds zymogen factor VII, the inactive precursor form; once bound, a variety of serine proteases rapidly activate factor VII to VIIa via limited proteolysis
  • Normally absent from all cells in direct contact with plasma
Positive staining - normal
  • Epidermal keratinocytes, glomerular epithelial cells and various other epithelia, adventitial cells of blood vessels, astrocytes, myocardium, Schwann cells, stromal cells of liver, pancreas, spleen and thyroid
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