CD Markers
CD154



Topic Completed: 1 February 2002

Minor changes: 9 October 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD154[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD154. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd154.html. Accessed January 15th, 2021.
Definition / general
  • Aka CD40 ligand, CD40L, TNF-related activation protein (TRAP)
  • Regulates B cell function by engaging CD40
  • Defective gene prevents immunoglobulin class switch and is associated with hyper IgM syndrome, autoimmune hematologic disorders, disorganized nodal follicular architecture and PAS-positive plasmacytoid cells containing IgM, lymph nodes without germinal centers, shortened lifespan, often with gastrointestinal cancers (cholangiocarcinoma, hepatocellular carcinoma, and adenocarcinoma) and Cryptosporidium parvum infection
Positive staining - normal
  • T cells
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