Cite this page: Pernick N. CD154. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd154.html. Accessed January 15th, 2021.
Definition / general
- Aka CD40 ligand, CD40L, TNF-related activation protein (TRAP)
- Regulates B cell function by engaging CD40
- Defective gene prevents immunoglobulin class switch and is associated with hyper IgM syndrome, autoimmune hematologic disorders, disorganized nodal follicular architecture and PAS-positive plasmacytoid cells containing IgM, lymph nodes without germinal centers, shortened lifespan, often with gastrointestinal cancers (cholangiocarcinoma, hepatocellular carcinoma, and adenocarcinoma) and Cryptosporidium parvum infection
Positive staining - normal
- T cells