CD Markers
CD15s
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD15s[title]
Related topics: CD15, CD15u
CD15s
Author: Nat Pernick, M.D.
Topic Completed: 1 January 2014
Minor changes: 2 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD15s[title]
Related topics: CD15, CD15u
Table of Contents
Definition / general | Clinical features | Pathophysiology | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD15s. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd15s.html. Accessed January 15th, 2021.
Definition / general
- Biochemically similar to CD15, but with different functions
- Also known as sialyl Lewis X
- Important in leukocyte tethering and rolling (Wikipedia)
Clinical features
- May be associated with refractory Hodgkin lymphoma (J Cancer 2012;3:322)
- Deficiency causes Rambam-Hasharon syndrome (OMIM #266265), also called leukocyte adhesion deficiency 2 (eMedicine)
- Expression is correlated with susceptibility to human granulocytic ehrlichiosis (J Clin Invest 1999;103:407)
- Elevated serum levels in hospitalized infants with serious bacterial infections (Eur J Pediatr 2013;172:1363
- Exhibits reversed cell polarity in invasive micropapillary carcinoma of breast (Int J Surg Pathol 2010;18:193)
Pathophysiology
- Differs from CD15 by addition of a sialic acid; myeloid maturation is accompanied by relative loss of CD15s and gain of CD15 expression (Nat Chem Biol 2008;4:751)
- Mediates leukocyte rolling (Proc Natl Acad Sci USA 1997;94:3172)
- Ligand (receptor) for CD62P and CD62E
- May play a role in cluster formation in lymphoid follicles (Immunol Lett 2001;79:181)
Uses by pathologists
- No significant clinical use by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Anti-CD15s antibody blocks infection of HL60 cells by HGE agent
Fluorescence associated with susceptibility to human granulocytic ehrlichiosis
Positive staining - normal
- Granulocytes, macrophages; also some T cells, B cells and NK cells
Positive staining - disease
- Cirrhosis, metastatic carcinoma, fibrolamellar and other hepatocellular carcinoma (Arch Pathol Lab Med 1992;116:643)
- CD4+ CD56+ neoplasia (Leuk Lymphoma 2003;44:281), Sezary syndrome (J Am Acad Dermatol 2001;44:456)
Negative staining
- Normal hepatocytes
