Stains & CD markers
CD160-169



Topic Completed: 1 February 2002

Minor changes: 24 June 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD160, CD161 [title], CD162 [title], CD163 [title], CD164 [title], CD165, CD166 [title], CD167, CD168 [title], CD169 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD160-169. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd160.html. Accessed October 24th, 2021.
CD160
  • Aka BY55
  • Expression tightly associated with peripheral blood NK cells and CD8+ T lymphocytes with cytolytic effector activity
  • Positive staining - normal: circulating NK (CD56 dim, CD116+) and T cells, spleen, small intestinal intraepithelial lymphocytes
CD161
  • Aka killer cell lectin-like receptor subfamily B, member 1
  • May mediate NK cell function
  • Positive staining - normal: NK cells, subset of CD4+ and CD8+ T cells, memory T cells, thymocytes (some)
CD162
  • Aka P-Selectin Glycoprotein Ligand 1 (PSGL-1)
  • Important in adhesive interactions between circulating leukocytes and platelets and endothelial cells
  • Mediates rolling on activated endothelium or activated platelets (which express P selectin / CD62P) and other leukocytes at inflammatory sites
  • Site of binding of human granulocyte ehrlichiosis bacteria
  • Positive staining - normal: myeloid cells, stimulated T cells
  • CD162R:
    • Aka PEN5
    • Positive staining - normal: NK cells
CD163
  • Hemoglobin / haptoglobin scavenger receptor
  • Soluble form attenuates immune response
  • Positive staining - normal: monocytes / macrophages
  • Positive staining - disease: histiocytic sarcoma (Diagn Pathol 2007;2:7)
CD164
  • Aka MUC-24, sialomucin
  • Mucin-like cell surface glycoprotein that facilitates adhesion of CD34+ cells
    • Regulates hematopoietic cell proliferation
  • Positive staining - normal: small and large bowel epithelia; lung, thyroid epithelia
  • Positive staining - disease: colorectal carcinoma, pancreatic adenocarcinoma
CD165
  • Involved in adhesion between thymocytes and thymic epithelial cells
  • Positive staining - normal: immature thymocytes, monocytes, platelets, CNS neurons, islet cells, Bowman's capsule of kidney
  • Positive staining - disease: many T acute lymphoblastic leukemias (ALL)
CD166
  • Aka Activated Leukocyte Cell Adhesion Molecule (ALCAM)
  • Adhesion molecule, binds to CD6
  • Involved in neuronal neurite extension, embryonic hemopoiesis, embryonic angiogenesis
  • Positive staining - normal: neurons, activated T cells, activated monocytes, epithelium, fibroblasts
CD167
  • Aka Discoidin Domain Receptor 1 (DDR1)
  • Has homologous region to the Dicytostelium discoideum protein discoidin I in extracellular domain
  • Tyrosine kinase receptor, may be important in cytoskeletal organization and the ability to align with other cells during aggregation
  • Receptor tyrosine kinases help cells communicate with their microenvironment and regulate cell growth, differentiation and metabolism
  • Activated by collagen types I - V, VIII
  • May have a role in tumor invasion and metastasis
  • Positive staining - normal: epithelial cells (breast, kidney, lung, GI, brain)
  • Positive staining - disease: carcinomas (various)
CD168
  • Aka Receptor for Hyaluronic Acid-Mediated Motility (RHAMM)
  • Binding to hyaluron stimulates ciliary beating
  • Also has role in cell signaling, migration and adhesion
  • Positive staining - normal: bronchial epithelium, CNS neurons
CD169
  • Aka sialoadhesin
  • Macrophage restricted cellular interaction molecule that binds sialylated ligands
  • Highly expressed on macrophages in chronically inflamed tissues, such as rheumatoid synovium and atherosclerotic plaques
  • Positive staining - normal: macrophages (all sites but microglia)
  • Negative staining: microglia
Microscopic (histologic) images

Contributed by Charles J. Sailey, M.D.,
Borislav A. Alexiev, M.D. and
John C. Papadimitriou, M.D.

Missing Image

CD163: histiocytic sarcoma


Contributed by
Jijgee Munkhdelger, M.D., Ph.D.
and Andrey Bychkov, M.D., Ph.D.

CD163: juvenile xanthogranuloma immunoprofile

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Image 01 Image 02