CD Markers

Topic Completed: 1 February 2002

Minor changes: 12 November 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD167

Nat Pernick, M.D.
Page views in 2020: 41
Page views in 2021 to date: 7
Cite this page: Pernick N. CD167a. website. Accessed January 16th, 2021.
Definition / general
  • A.K.A. Discoidin Domain Receptor 1 (DDR1)
  • Has homologous region to the Dicytostelium discoideum protein discoidin I in extracellular domain
  • Tyrosine kinase receptor, may be important in cytoskeletal organization and the ability to align with other cells during aggregation
  • Receptor tyrosine kinases help cells communicate with their microenvironment and regulate cell growth, differentiation and metabolism
  • Activated by collagen types I - V, VIII
  • May have a role in tumor invasion and metastasis
Positive staining - normal
  • Epithelial cells (breast, kidney, lung, GI, brain)
Positive staining - disease
  • Carcinomas (various)
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