CD Markers
CD167a
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD167
CD167a
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 12 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD167
Cite this page: Pernick N. CD167a. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd167.html. Accessed January 16th, 2021.
Definition / general
- A.K.A. Discoidin Domain Receptor 1 (DDR1)
- Has homologous region to the Dicytostelium discoideum protein discoidin I in extracellular domain
- Tyrosine kinase receptor, may be important in cytoskeletal organization and the ability to align with other cells during aggregation
- Receptor tyrosine kinases help cells communicate with their microenvironment and regulate cell growth, differentiation and metabolism
- Activated by collagen types I - V, VIII
- May have a role in tumor invasion and metastasis
Positive staining - normal
- Epithelial cells (breast, kidney, lung, GI, brain)
Positive staining - disease
- Carcinomas (various)
