CD Markers
CD16b
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD16b[title]
Related topics: CD16a
CD16b
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2013
Minor changes: 2 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD16b[title]
Related topics: CD16a
Table of Contents
Definition / general | Pathophysiology | Uses by pathologists | Positive staining - normalCite this page: Pernick N. CD16b. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd16b.html. Accessed January 15th, 2021.
Definition / general
- The most common receptor for the Fc domain of IgG on leukocytes
- Also known as Fc gamma receptor III B, low affinity immunoglobulin gamma Fc region receptor III-B
- Has allotypes that define the human neutrophil antigen-1 (HNA-1 and NA) system involved in major post-transfusional reactions (Tissue Antigens 2004;64:119)
- Polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis (Lung 2010;188:475)
- Polymorphisms may be associated with malaria (PLoS One 2012;7:e46197, Hum Genet 2012;131:289)
- Low copy number is associated with glomerulonephritis in systemic lupus erythematosus (Nature 2006;439:851)
- CD16+ eosinophils are upregulated in allergic conditions (J Allergy Clin Immunol 2002;109:463)
Pathophysiology
- Highly homologous to CD16a
- The only Fc receptor linked to the plasma membrane by a GPI (glycosylphosphatidylinositol) anchor
- Occurs in two codominantly expressed allelic variants, NA1 and NA2, which exhibit different binding affinities for IgG1 and IgG3 subclasses
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Neutrophils, basophils (J Immunol 2009;182:2542)
